Uptake Medical Corporation, Tustin, California 92780, USA.
Int J Hyperthermia. 2012;28(5):466-72. doi: 10.3109/02656736.2012.677932. Epub 2012 Jun 12.
An investigation of the thermal effect and the potential for injury at the lung surface following thermal vapour ablation (InterVapor), an energy-based method of achieving endoscopic lung volume reduction.
Heated water vapour was delivered to fifteen ex vivo human lungs using standard clinical procedure, and the thermal effect at the visceral pleura was monitored with an infrared camera. The time-temperature response was analysed mathematically to determine a cumulative injury quotient, which was compared to published thresholds.
The cumulative injury quotients for all 71 treatments of ex vivo tissue were found to be below the threshold for first degree burn and no other markers of tissue injury at the lung surface were observed.
The safety profile for thermal vapour ablation is further supported by the demonstration that the thermal effect in a worst-case model is not expected to cause injury at the lung surface.
研究热能对肺表面的影响以及潜在的损伤，热能是实现内镜下肺减容的一种能量方法。
采用标准临床程序向 15 个离体人肺输送加热水蒸气，并使用红外摄像机监测内脏胸膜的热效应。通过数学分析时间-温度响应来确定累积损伤商，并与已发表的阈值进行比较。
发现所有 71 例离体组织的累积损伤商均低于一度烧伤的阈值，且未观察到肺表面其他组织损伤的标志物。
热能蒸汽消融的安全性进一步得到支持，证明在最坏情况下的热效应预计不会导致肺表面损伤。
