Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy.
J Biol Regul Homeost Agents. 2012 Jan-Mar;26(1 Suppl):S105-8.
PTX3 behaves as an acute-phase response protein as its blood levels rapidly and dramatically increase during endotoxic shock, sepsis, and other inflammatory and infectious conditions. Therefore, this study was designed to investigate a possible role of PTX3 in children with Atopic Dermatitis (AD). One-hundred-and-thirty-six patients (37 females, 99 males, mean age 10.4 years) were enrolled in the study. One hundred patients (74%) had only respiratory symptoms (allergic rhinitis and/or bronchial asthma); thirty-six patients (26%) showed dermatitis associated with respiratory allergy (allergic rhinitis and/or bronchial asthma). PTX3 levels were higher in children with AD and there was a significant correlation between serum PTX3 levels and SCORAD index (p-value=0.0001, rho=0.658). Therefore, this study may show that PTX3 might be a reliable marker for the severity of AD in children with respiratory allergy.
PTX3 是一种急性反应蛋白，在内毒素休克、败血症和其他炎症及感染性疾病中，其血液水平会迅速而显著地升高。因此，本研究旨在探讨 PTX3 在特应性皮炎（AD）患儿中的可能作用。
共纳入 136 例患儿（37 名女性，99 名男性，平均年龄 10.4 岁）。100 例（74%）患儿仅有呼吸道症状（变应性鼻炎和/或支气管哮喘）；36 例患儿（26%）表现为与呼吸道过敏相关的皮炎（变应性鼻炎和/或支气管哮喘）。AD 患儿的 PTX3 水平较高，血清 PTX3 水平与 SCORAD 指数之间存在显著相关性（p 值=0.0001，rho=0.658）。
因此，本研究可能表明，PTX3 可能是儿童呼吸道过敏患者 AD 严重程度的可靠标志物。
