Koth Kevin, Boniface James, Chance Elisha A, Hanes Marina C
Orthopedics. 2012 Jun;35(6):e996-9. doi: 10.3928/01477447-20120525-52.
Enterobacter asburiae and Aeromonas hydrophila are gram-negative bacilli that have been isolated in soil and water. Enterobacter asburiae can cause an array of diseases, and exposure to A hydrophila can cause soft tissue infections, including necrotizing faciitis.A healthy-appearing 22-year-old man presented with an innocuous soft tissue injury to his leg due to an all-terrain vehicle crash. He received intravenous antibiotics and was discharged with prophylactic oral antibiotics. After the rapid onset of high fevers (102°F-103°F) <24 hours postinjury, he returned to the emergency department. Emergent surgical debridement was performed, and broad-spectrum intravenous antibiotics were started. Fevers persisted, and the patient underwent repeat extensive surgical debridement and antibiotic bead placement <30 hours after the initial surgical debridement and broad-spectrum antibiotics. Intraoperative cultures found E asburiae and A hydrophila in the wound. Following a long course of antibiotics and a skin graft, he fully recovered and had no functional deficits 1 year postoperatively.Extensive research revealed that these organisms are rare in soft tissue infections. E asburiae is opportunistic but has not been reported as a primary wound organism, and A hydrophila infections have been reported following motor vehicle crashes involving wound contamination. At presentation, it is challenging to determine rare organisms in a timely fashion; however, emergent extensive surgical intervention of an accelerated aberrant disease process should be considered to avoid catastrophic outcomes.
阿氏肠杆菌和嗜水气单胞菌是在土壤和水中分离出的革兰氏阴性杆菌。阿氏肠杆菌可引发一系列疾病,接触嗜水气单胞菌可导致软组织感染,包括坏死性筋膜炎。一名看似健康的22岁男性因全地形车事故导致腿部出现看似无害的软组织损伤。他接受了静脉注射抗生素治疗,并在出院时带了预防性口服抗生素。受伤后不到24小时,他迅速出现高热(华氏102度至103度),随后返回急诊室。进行了紧急外科清创术,并开始使用广谱静脉抗生素。发热持续,患者在初次外科清创术和使用广谱抗生素后不到30小时,再次接受了广泛的外科清创术并放置了抗生素珠。术中培养发现伤口中有阿氏肠杆菌和嗜水气单胞菌。经过长时间的抗生素治疗和皮肤移植,他完全康复,术后1年没有功能缺陷。广泛研究表明,这些微生物在软组织感染中很罕见。阿氏肠杆菌是机会致病菌,但尚未有作为原发性伤口病原体的报道,而嗜水气单胞菌感染在涉及伤口污染的机动车事故后有过报道。在就诊时,及时确定罕见病原体具有挑战性;然而,应考虑对加速的异常疾病进程进行紧急广泛的外科干预,以避免灾难性后果。