Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Adv Anat Pathol. 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92.
Beyond the typical acinar morphology observed in the majority of prostatic adenocarcinomas, a spectrum of morphologic variants and prostate cancer subtypes exists. These unusual entities may be classified as: (1) cancer morphologies arising by divergent differentiation of prostatic ductal, acinar, or basal cells and associated with unique clinical features and/or therapeutic approaches, and (2) histologies occurring in the context of usual prostatic adenocarcinoma that may result in diagnostic misinterpretation or difficulties in Gleason grade assignment, especially in limited samples. This article details a number of variants, with emphasis on diagnostic criteria, differential diagnoses, and clinical significance.
除了大多数前列腺腺癌中观察到的典型腺泡形态外，还存在一系列形态变异型和前列腺癌亚型。这些不常见的实体可以分为：(1) 由前列腺导管、腺泡或基底细胞的分歧分化引起的癌形态，与独特的临床特征和/或治疗方法相关；(2) 在常见前列腺腺癌背景下发生的组织学，可能导致诊断误解或在格里森分级分配方面的困难，尤其是在有限的样本中。本文详细介绍了一些变体，重点介绍了诊断标准、鉴别诊断和临床意义。
