Shibata A, Asano A, Hamajima N, Sasaki R, Aoki K, Yokoyama H, Yokoyama Y
Department of Preventive Medicine, Nagoya University School of Medicine, Japan.
Environ Health Perspect. 1990 Jul;87:37-41. doi: 10.1289/ehp.908737.
A preliminary result from a cohort study on the association of a family history of cancer with mortality is discussed in this paper. Among 2200 patients (1912 males and 288 females) gastrectomized because of benign gastric diseases, 274 male patients, and 40 female patients had a family history of cancer. During 2750 person-years of observation, 22 patients with the family history of cancer were found to be dead and 111 patients without the family history died during 17,527 person-years, giving a relative risk of 1.26 (not significant). We focused on the male subjects that were followed up for more than 10 years; however, the observed/expected ratio of cancer deaths for subjects with a family history of cancer was about four times higher than that for those without family history. Since case-control studies on family history are vulnerable to biased recall and interchangeability of cases, more cohort studies like the present study should be conducted to assess the association of the family history of cancer.
本文讨论了一项关于癌症家族史与死亡率关联的队列研究的初步结果。在因良性胃部疾病接受胃切除手术的2200名患者（1912名男性和288名女性）中，274名男性患者和40名女性患者有癌症家族史。在2750人年的观察期内，有癌症家族史的22名患者死亡，在17527人年中，无癌症家族史的111名患者死亡，相对风险为1.26（无统计学意义）。我们关注了随访超过10年的男性受试者；然而，有癌症家族史的受试者的癌症死亡观察/预期比率比无家族史的受试者高出约四倍。由于关于家族史的病例对照研究容易受到回忆偏倚和病例互换性的影响，应该开展更多像本研究这样的队列研究来评估癌症家族史的关联。
