Center for Cancer and Stem Cell Biology, Alkek Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, USA.
Cancer Metastasis Rev. 2012 Dec;31(3-4):585-91. doi: 10.1007/s10555-012-9367-7.
KiSS1 and its cognate G-protein-coupled receptor, GPR54, have diverse functions. While KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still unclear. In cancer, KiSS1 and GPR54 have been known to suppress metastasis by inhibiting cancer cell motility. However, recent studies suggest that KiSS1 and GPR54 have varied roles even in cancer development and metastasis. Here, we examine recent advances in understanding the roles of KiSS1 and GPR54 in cancer development and metastasis.
KiSS1 及其同源的 G 蛋白偶联受体 GPR54 具有多种功能。虽然 KiSS1 和 GPR54 在生理学方面已经得到了深入研究，但它们在癌症中的作用仍不清楚。在癌症中，KiSS1 和 GPR54 通过抑制癌细胞迁移来抑制转移已被广泛研究。然而，最近的研究表明，KiSS1 和 GPR54 在癌症的发展和转移中甚至具有不同的作用。在这里，我们探讨了对 KiSS1 和 GPR54 在癌症发展和转移中作用的最新理解进展。
