KISS1 在转移性癌症研究与治疗中的作用：潜力与悖论。
KISS1 in metastatic cancer research and treatment: potential and paradoxes.
机构信息
Department of Cancer Biology, Kansas University Medical Center, 3901 Rainbow Blvd. - MS1071, Kansas City, KS, 66160, USA.
Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
出版信息
Cancer Metastasis Rev. 2020 Sep;39(3):739-754. doi: 10.1007/s10555-020-09868-9.
Abstract
The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its function as a neuropeptide involved in diverse physiologic processes is more well studied. Enthusiasm regarding KISS1 has cumulated in clinical trials in multiple fields related to reproduction and metabolism. But its cancer therapeutic space is unsettled. This review focuses on collating data from cancer and non-cancer fields in order to understand shared and disparate signaling that might inform clinical development in the cancer therapeutic and biomarker space. Research has focused on amino acid residues 68-121 (kisspeptin 54), binding to the KISS1 receptor and cellular responses. Evidence and counterevidence regarding this canonical pathway require closer look at the covariates so that the incredible potential of KISS1 can be realized.
摘要
KISS1 的意义不仅在于其最初作为转移抑制因子的发现。它作为一种参与多种生理过程的神经肽的功能研究得更加深入。人们对 KISS1 的热情在生殖和代谢等多个领域的临床试验中得到了体现。但它在癌症治疗方面的应用尚未确定。这篇综述重点整理了癌症和非癌症领域的数据，以了解共同和不同的信号通路，为癌症治疗和生物标志物领域的临床开发提供信息。研究主要集中在氨基酸残基 68-121（促黑激素 54）与 KISS1 受体的结合以及细胞反应上。关于这个经典途径的证据和反证需要更仔细地考虑协变量，以便充分发挥 KISS1 的巨大潜力。
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