Pycock J F, Allen W E
Department of Surgery and Obstetrics, Royal Veterinary College, Hatfield, Hertfordshire, UK.
Equine Vet J. 1990 Nov;22(6):422-5. doi: 10.1111/j.2042-3306.1990.tb04309.x.
Exudate and uterine flushings were collected at either 30, 60, 120 or 240 mins after intrauterine infusions of Streptococcus zooepidemicus in genitally normal mares during oestrus. Uteri were also flushed without prior induction of endometritis. Protein concentrations in exudate and flushings increased with time and exudate pH decreased with time; the pH of flushings did not alter. Lysozyme and lactate dehydrogenase were present in flushings from non-infected uteri, but concentrations increased with time after infection. Immunoreactive prostaglandin E2 was undetectable before infection, but concentrations rose after infection. No neutrophils were present in non-infected flushings but, by 30 mins, there were significant (P less than 0.01) neutrophil numbers in exudate and flushings; thereafter numbers increased, particularly in exudate. Acute endometritis resembled acute inflammation at other sites in the horse and a significant response had occurred by 30 mins after experimental infection.
在发情期对生殖系统正常的母马进行子宫内输注兽疫链球菌后，于30、60、120或240分钟收集渗出液和子宫冲洗液。子宫也在未预先诱发子宫内膜炎的情况下进行冲洗。渗出液和冲洗液中的蛋白质浓度随时间增加，渗出液的pH值随时间降低；冲洗液的pH值没有变化。溶菌酶和乳酸脱氢酶存在于未感染子宫的冲洗液中，但感染后其浓度随时间增加。感染前未检测到免疫反应性前列腺素E2，但感染后浓度升高。未感染的冲洗液中没有中性粒细胞，但在30分钟时，渗出液和冲洗液中的中性粒细胞数量显著增加（P<0.01）；此后数量增加，尤其是在渗出液中。急性子宫内膜炎类似于马其他部位的急性炎症，实验感染后30分钟就出现了显著反应。
