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抢救低体温性难治性高碳酸血症。

Rescue hypothermia for refractory hypercapnia.

机构信息

Pediatric Intensive Care Unit, Department of Emergency and Intensive Care, University Hospital "A. Gemelli", Catholic University of the Sacred Heart, Rome, Italy.

出版信息

Eur J Pediatr. 2012 Dec;171(12):1855-7. doi: 10.1007/s00431-012-1769-6. Epub 2012 Jun 13.

DOI:10.1007/s00431-012-1769-6
PMID:22692802
Abstract

Hypothermia may reduce the CO(2) production by decreasing the metabolism of the cooled tissue. We describe the first clinical use of hypothermia to lower hypercarbia in a case of bronchiolitis related respiratory failure unresponsive to maximal respiratory support. In this case, hypothermia allowed sparing the use of extracorporeal life support. Conclusion Hypothermia might be useful for severe acute respiratory failure unresponsive to aggressive respiratory support.

摘要

低温可能通过降低冷却组织的代谢来减少 CO2 的产生。我们描述了首例使用低温治疗因细支气管炎导致呼吸衰竭而对最大呼吸支持无反应的患者的高碳酸血症。在这种情况下,低温可避免使用体外生命支持。结论低温可能对严重的急性呼吸衰竭,对积极的呼吸支持无反应的情况下有用。

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Rescue hypothermia for refractory hypercapnia.抢救低体温性难治性高碳酸血症。
Eur J Pediatr. 2012 Dec;171(12):1855-7. doi: 10.1007/s00431-012-1769-6. Epub 2012 Jun 13.
2
[Bronchiolitis (RS virus infection)].[细支气管炎(呼吸道合胞病毒感染)]
Nihon Rinsho. 2003 Feb;61 Suppl 2:151-5.
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Respiratory syncytial virus infection and bronchiolitis.呼吸道合胞病毒感染与细支气管炎
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Fatal coronary artery anomaly presenting as bronchiolitis.表现为细支气管炎的致命性冠状动脉异常。
Eur J Pediatr. 2006 Jul;165(7):505; author reply 506. doi: 10.1007/s00431-005-0079-7. Epub 2006 Apr 7.
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[Bronchiolitis in infants. Are there severity criteria for hospitalization?].
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Risk factors for hypoxemia and respiratory failure in respiratory syncytial virus bronchiolitis.呼吸道合胞病毒细支气管炎中低氧血症和呼吸衰竭的危险因素。
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J Perinatol. 2025 Apr 2. doi: 10.1038/s41372-025-02285-2.
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Severe Hypercapnia Requiring 48-h Whole-Body Hypothermia in an Infant with Acute Bronchiolitis.一名急性细支气管炎婴儿出现严重高碳酸血症,需进行48小时全身低温治疗。
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本文引用的文献

1
Neuroprotection and hypothermia in infants and children.神经保护和婴儿及儿童的低温疗法。
Curr Drug Targets. 2012 Jun;13(7):925-35. doi: 10.2174/138945012800675641.
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Intrapulmonary drug administration in neonatal and paediatric critical care: a comprehensive review.肺内给药在新生儿和儿科危重症中的应用:全面综述。
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The effect of induced hypothermia on respiratory parameters in mechanically ventilated patients.诱导性低温对机械通气患者呼吸参数的影响。
控制性低温可能会改善患有或未患有胎粪吸入综合征的窒息新生儿的表面活性物质功能。
PLoS One. 2018 Feb 8;13(2):e0192295. doi: 10.1371/journal.pone.0192295. eCollection 2018.
4
Does Whole-Body Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy Affect Surfactant Disaturated-Phosphatidylcholine Kinetics?新生儿缺氧缺血性脑病全身低温治疗是否会影响表面活性物质二饱和磷脂酰胆碱的动力学?
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Body temperature effects on lung injury in ventilated preterm lambs.体温对机械通气早产儿肺损伤的影响。
Resuscitation. 2010 Jun;81(6):749-54. doi: 10.1016/j.resuscitation.2009.12.007. Epub 2010 Mar 17.
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Mechanisms of action, physiological effects, and complications of hypothermia.体温过低的作用机制、生理效应及并发症。
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Surfactant therapy for bronchiolitis in critically ill infants.危重症婴儿毛细支气管炎的表面活性剂治疗
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Developmental and neurologic effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants.婴儿深低温体外循环中α稳态与pH稳态策略的发育和神经学影响
J Thorac Cardiovasc Surg. 2001 Feb;121(2):374-83. doi: 10.1067/mtc.2001.111206.