起始联合抗逆转录病毒疗法后的大脑结构和功能恢复。
Brain structural and functional recovery following initiation of combination antiretroviral therapy.
机构信息
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
J Neurovirol. 2012 Oct;18(5):423-7. doi: 10.1007/s13365-012-0115-0. Epub 2012 Jun 13.
Abstract
NeuroAIDS persists in the era of combination antiretroviral therapies. We describe here the recovery of brain structure and function following 6 months of therapy in a treatment-naive patient presenting with HIV-associated dementia. The patient's neuropsychological test performance improved and his total brain volume increased by more than 5 %. Neuronal functional connectivity measured by magnetoencephalography changed from a pattern identical to that observed in other HIV-infected individuals to one that was indistinguishable from that of uninfected control subjects. These data suggest that at least some of the effects of HIV on the brain can be fully reversed with treatment.
摘要
神经艾滋病在联合抗逆转录病毒疗法时代仍然存在。我们在此描述了一名未经治疗的 HIV 相关痴呆患者在接受 6 个月治疗后的大脑结构和功能恢复情况。患者的神经心理学测试表现得到改善，大脑总容积增加超过 5%。通过脑磁图测量的神经元功能连接从与其他 HIV 感染者相同的模式转变为与未感染对照受试者无法区分的模式。这些数据表明，至少部分 HIV 对大脑的影响可以通过治疗完全逆转。
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