Tolo Diebkilé Aïssata, Kouakou Boidy, N'dhatz Emeraude, Nanho Clotaire D, Meité N'dogomo, Ayémou Roméo, Sekongo Mamadou Y, Kouéhion Paul, Konan Mozart, Koffi Gustave K, Sanogo Ibrahima
Department of Clinical Hematology, Yopougon Teaching Hospital, P.O. Box 632, Abidjan 21, Cote d'Ivoire.
Adv Hematol. 2012;2012:945138. doi: 10.1155/2012/945138. Epub 2012 May 28.
Diffuse large B-cell lymphomas have been little studied in black Africans. The purpose of our study was to determine the characteristics and results of the management of these lymphomas. Patients and Methods. In a descriptive and analytic retrospective study we studied the medical records of 63 patients with diffuse large B-cell lymphoma hospitalized during the period from 1991 to 2007. The diagnosis was made after lymph node or organ biopsy. Response to treatment, OS, PFS, and toxicity were studied. The complete response has been analyzed univariate and multivariate analysis. Results. The median age was 42 years. The sex ratio was 2. The HIV serology was positive in 11 cases, and 8 patients had antiretroviral therapy. In 71% the lymphoma was at stages III and IV of Ann Arbor. IPI was ≥3 in 65%. Complete remission was achieved in 43%. Only 43% of patients had had a good compliance. Progression-free survival at 3 years was 32%, and overall survival at 3 years was 50%. 13% of patients were lost to follow up, and 51% of them died. In terms of analysis the complete remission rate was influenced by the stage of Ann Arbor (P < 0.0001), biological b symptoms (P < 0.01), the IPI (P < 0.0001), and the socioeconomic standing (P = 0.001). In multivariate analysis, only IPI and stage of Ann Arbor influence the complete remission.
在非洲黑人中，弥漫性大B细胞淋巴瘤的研究较少。我们研究的目的是确定这些淋巴瘤的特征及治疗结果。患者与方法。在一项描述性和分析性回顾性研究中，我们研究了1991年至2007年期间住院的63例弥漫性大B细胞淋巴瘤患者的病历。诊断通过淋巴结或器官活检做出。研究了治疗反应、总生存期（OS）、无进展生存期（PFS）和毒性。对完全缓解进行了单因素和多因素分析。结果。中位年龄为42岁。男女比例为2。11例患者HIV血清学呈阳性，8例患者接受了抗逆转录病毒治疗。71%的淋巴瘤处于Ann Arbor分期的III期和IV期。65%的患者国际预后指数（IPI）≥3。43%的患者实现了完全缓解。只有43%的患者依从性良好。3年无进展生存率为32%，3年总生存率为50%。13%的患者失访，其中51%死亡。在分析方面，完全缓解率受Ann Arbor分期（P < 0.0001）、生物学B症状（P < 0.01）、IPI（P < 0.0001）和社会经济地位（P = 0.001）影响。在多因素分析中，只有IPI和Ann Arbor分期影响完全缓解。
