胃癌中的T细胞：朋友还是敌人？
T cells in gastric cancer: friends or foes.
作者信息
Amedei Amedeo, Della Bella Chiara, Silvestri Elena, Prisco Domenico, D'Elios Mario M
机构信息
Patologia Medica, Dipartimento de Biomedicina, Azienda Ospedaliera Universitaria Careggi, Largo Brambilla 3, 50134 Firenze, Italy.
出版信息
Clin Dev Immunol. 2012;2012:690571. doi: 10.1155/2012/690571. Epub 2012 May 31.
Abstract
Gastric cancer is the second cause of cancer-related deaths worldwide. Helicobacter pylori is the major risk factor for gastric cancer. As for any type of cancer, T cells are crucial for recognition and elimination of gastric tumor cells. Unfortunately T cells, instead of protecting from the onset of cancer, can contribute to oncogenesis. Herein we review the different types, "friend or foe", of T-cell response in gastric cancer.
摘要
胃癌是全球癌症相关死亡的第二大原因。幽门螺杆菌是胃癌的主要危险因素。对于任何类型的癌症而言，T细胞对于识别和清除胃肿瘤细胞至关重要。不幸的是，T细胞非但不能预防癌症的发生，反而可能促进肿瘤发生。在此，我们综述胃癌中不同类型的T细胞反应，即“友”或“敌”。
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