• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胃癌中的T细胞：朋友还是敌人？

T cells in gastric cancer: friends or foes.

作者信息

Amedei Amedeo, Della Bella Chiara, Silvestri Elena, Prisco Domenico, D'Elios Mario M

机构信息

Patologia Medica, Dipartimento de Biomedicina, Azienda Ospedaliera Universitaria Careggi, Largo Brambilla 3, 50134 Firenze, Italy.

出版信息

Clin Dev Immunol. 2012;2012:690571. doi: 10.1155/2012/690571. Epub 2012 May 31.

DOI:10.1155/2012/690571
PMID:22693525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3369415/
Abstract

Gastric cancer is the second cause of cancer-related deaths worldwide. Helicobacter pylori is the major risk factor for gastric cancer. As for any type of cancer, T cells are crucial for recognition and elimination of gastric tumor cells. Unfortunately T cells, instead of protecting from the onset of cancer, can contribute to oncogenesis. Herein we review the different types, "friend or foe", of T-cell response in gastric cancer.

摘要

胃癌是全球癌症相关死亡的第二大原因。幽门螺杆菌是胃癌的主要危险因素。对于任何类型的癌症而言，T细胞对于识别和清除胃肿瘤细胞至关重要。不幸的是，T细胞非但不能预防癌症的发生，反而可能促进肿瘤发生。在此，我们综述胃癌中不同类型的T细胞反应，即“友”或“敌”。

相似文献

1
T cells in gastric cancer: friends or foes.胃癌中的T细胞：朋友还是敌人？
Clin Dev Immunol. 2012;2012:690571. doi: 10.1155/2012/690571. Epub 2012 May 31.
2
Bone marrow-derived mesenchymal stem cells favor the immunosuppressive T cells skewing in a Helicobacter pylori model of gastric cancer.骨髓间充质干细胞有利于在胃癌的幽门螺杆菌模型中偏向免疫抑制性 T 细胞。
Stem Cells Dev. 2013 Nov 1;22(21):2836-48. doi: 10.1089/scd.2013.0166. Epub 2013 Aug 16.
3
Prevalence of Th17 and Treg cells in gastric cancer patients and its correlation with clinical parameters.胃癌患者中 Th17 和 Treg 细胞的流行及其与临床参数的相关性。
Oncol Rep. 2013 Sep;30(3):1215-22. doi: 10.3892/or.2013.2570. Epub 2013 Jun 27.
4
The lipoprotein HP1454 of Helicobacter pylori regulates T-cell response by shaping T-cell receptor signalling.幽门螺杆菌的脂蛋白 HP1454 通过塑造 T 细胞受体信号来调节 T 细胞反应。
Cell Microbiol. 2019 May;21(5):e13006. doi: 10.1111/cmi.13006. Epub 2019 Jan 31.
5
Association of intra-tumoral infiltrating macrophages and regulatory T cells is an independent prognostic factor in gastric cancer after radical resection.肿瘤内浸润巨噬细胞和调节性 T 细胞的相关性是根治性切除术后胃癌的独立预后因素。
Ann Surg Oncol. 2011 Sep;18(9):2585-93. doi: 10.1245/s10434-011-1609-3. Epub 2011 Feb 23.
6
MiR-21 Participates in the PD-1/PD-L1 Pathway-Mediated Imbalance of Th17/Treg Cells in Patients After Gastric Cancer Resection.miR-21 参与胃癌切除术后患者 PD-1/PD-L1 通路介导的 Th17/Treg 细胞失衡。
Ann Surg Oncol. 2019 Mar;26(3):884-893. doi: 10.1245/s10434-018-07117-6. Epub 2018 Dec 18.
7
ICOS Foxp3 TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori.胃癌中ICOS Foxp3肿瘤浸润淋巴细胞是预后标志物及与幽门螺杆菌相关的效应调节性T细胞。
Int J Cancer. 2017 Feb 1;140(3):686-695. doi: 10.1002/ijc.30475. Epub 2016 Oct 27.
8
Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer.促炎滤泡辅助性T细胞促进免疫球蛋白G分泌，抑制调节性B细胞发育，并与胃癌较差的临床结果相关。
Tumour Biol. 2017 Jun;39(6):1010428317705747. doi: 10.1177/1010428317705747.
9
B-cell receptor signaling and CD40 ligand-independent T cell help cooperate in Helicobacter-induced MALT lymphomagenesis.B 细胞受体信号和 CD40 配体非依赖性 T 细胞辅助协同作用于幽门螺杆菌诱导的 MALT 淋巴瘤发生。
Leukemia. 2010 Jun;24(6):1186-96. doi: 10.1038/leu.2010.76. Epub 2010 Apr 29.
10
Gastric cancer tissue-derived mesenchymal stem cells impact peripheral blood mononuclear cells via disruption of Treg/Th17 balance to promote gastric cancer progression.胃癌组织来源的间充质干细胞通过破坏Treg/Th17平衡影响外周血单个核细胞，从而促进胃癌进展。
Exp Cell Res. 2017 Dec 1;361(1):19-29. doi: 10.1016/j.yexcr.2017.09.036. Epub 2017 Sep 28.

引用本文的文献

1
Comprehensive Analysis of Granzymes and Perforin Family Genes in Multiple Cancers.多种癌症中颗粒酶和穿孔素家族基因的综合分析
Biomedicines. 2025 Feb 7;13(2):408. doi: 10.3390/biomedicines13020408.
2
HOXC12 promotes the invasion and migration of gastric cancer cells by upregulating SALL4 and activating Wnt/β-catenin signaling pathway.HOXC12通过上调SALL4并激活Wnt/β-连环蛋白信号通路来促进胃癌细胞的侵袭和迁移。
Discov Oncol. 2024 Nov 5;15(1):620. doi: 10.1007/s12672-024-01502-2.
3
Dysregulation of systemic immunity and its clinical application in gastric cancer.系统性免疫失调及其在胃癌中的临床应用。
Front Immunol. 2024 Sep 5;15:1450128. doi: 10.3389/fimmu.2024.1450128. eCollection 2024.
4
Ascites-derived hsa-miR-181a-5p serves as a prognostic marker for gastric cancer-associated malignant ascites.腹水来源的 hsa-miR-181a-5p 可作为胃癌相关恶性腹水的预后标志物。
BMC Genomics. 2024 Jun 24;25(1):628. doi: 10.1186/s12864-024-10359-2.
5
Prognostic significance and immune characteristics of GPR27 in gastric cancer.GPR27 在胃癌中的预后意义及免疫特征。
Aging (Albany NY). 2023 Sep 12;15(17):9144-9166. doi: 10.18632/aging.205023.
6
The Present and Future of Neoadjuvant and Adjuvant Therapy for Locally Advanced Gastric Cancer.局部进展期胃癌新辅助和辅助治疗的现状与未来
Cancers (Basel). 2023 Aug 15;15(16):4114. doi: 10.3390/cancers15164114.
7
PD-L1 testing in advanced gastric cancer-what physicians who treat this disease must know-a literature review.晚期胃癌中的程序性死亡受体配体1检测——治疗该疾病的医生必须了解的内容——文献综述
J Gastrointest Oncol. 2023 Jun 30;14(3):1560-1575. doi: 10.21037/jgo-22-1133. Epub 2023 May 11.
8
Gastric Cancer and the Immune System: The Key to Improving Outcomes?胃癌与免疫系统：改善治疗结果的关键？
Cancers (Basel). 2022 Nov 30;14(23):5940. doi: 10.3390/cancers14235940.
9
The immune microenvironment in gastric adenocarcinoma.胃腺癌的免疫微环境。
Nat Rev Gastroenterol Hepatol. 2022 Jul;19(7):451-467. doi: 10.1038/s41575-022-00591-0. Epub 2022 Mar 14.
10
Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature.外周细胞因子水平作为胃癌的预后指标：现有文献综述
Biomedicines. 2021 Dec 14;9(12):1916. doi: 10.3390/biomedicines9121916.

本文引用的文献

1
T-cell-inducing vaccines - what's the future.T 细胞诱导疫苗——未来如何。
Immunology. 2012 Jan;135(1):19-26. doi: 10.1111/j.1365-2567.2011.03517.x.
2
Deciphering the role of Th17 cells in human disease.解析 Th17 细胞在人类疾病中的作用。
Trends Immunol. 2011 Dec;32(12):603-11. doi: 10.1016/j.it.2011.08.003. Epub 2011 Sep 28.
3
Cytokine induced killer cells as promising immunotherapy for solid tumors.细胞因子诱导的杀伤细胞作为实体瘤有前途的免疫疗法。
J Cancer. 2011;2:363-8. doi: 10.7150/jca.2.363. Epub 2011 Jun 15.
4
Dual roles of immune cells and their factors in cancer development and progression.免疫细胞及其因子在癌症发生发展中的双重作用。
Int J Biol Sci. 2011;7(5):651-8. doi: 10.7150/ijbs.7.651. Epub 2011 May 21.
5
Gastric cancer cells induce human CD4+Foxp3+ regulatory T cells through the production of TGF-β1.胃癌细胞通过产生 TGF-β1 诱导人 CD4+Foxp3+调节性 T 细胞。
World J Gastroenterol. 2011 Apr 21;17(15):2019-27. doi: 10.3748/wjg.v17.i15.2019.
6
Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies.十年癌症疫苗接种进展：未来治疗中需要双重靶向以克服癌症逃逸。
Cancer Immunol Immunother. 2011 Aug;60(8):1127-35. doi: 10.1007/s00262-011-0985-7. Epub 2011 Apr 9.
7
Adoptive immunotherapy of human gastric cancer with ex vivo expanded T cells.体外扩增 T 细胞的人胃癌过继免疫治疗。
Arch Pharm Res. 2010 Nov;33(11):1789-95. doi: 10.1007/s12272-010-1111-7. Epub 2010 Nov 30.
8
Generation and differentiation of IL-17-producing CD4+ T cells in malignant pleural effusion.恶性胸腔积液中产生白细胞介素-17 的 CD4+T 细胞的生成和分化。
J Immunol. 2010 Nov 15;185(10):6348-54. doi: 10.4049/jimmunol.1001728. Epub 2010 Oct 15.
9
Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer.肿瘤微环境中Th17细胞的诱导可提高胰腺癌小鼠模型的生存率。
J Immunol. 2010 Oct 1;185(7):4063-71. doi: 10.4049/jimmunol.0902609. Epub 2010 Aug 30.
10
Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma.外周血和肿瘤浸润淋巴细胞中调节性 T 细胞的频率与肾细胞癌的预后不良相关。
BJU Int. 2011 May;107(9):1500-6. doi: 10.1111/j.1464-410X.2010.09555.x. Epub 2010 Aug 24.