无冷冻保存的自体造血干细胞移植治疗多发性骨髓瘤
Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma without Cryopreservation.
作者信息
Al-Anazi Khalid Ahmed
机构信息
Section of Adult Hematology and Hematopoietic Stem Cell Transplantation, Oncology Center, King Fahad Specialist Hospital, P.O. Box 15215, Dammam 31444, Saudi Arabia.
出版信息
Bone Marrow Res. 2012;2012:917361. doi: 10.1155/2012/917361. Epub 2012 May 28.
Abstract
High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation is considered the standard of care for multiple myeloma patients who are eligible for transplantation. The process of autografting comprises the following steps: control of the primary disease by using a certain induction therapeutic protocol, mobilization of stem cells, collection of mobilized stem cells by apheresis, cryopreservation of the apheresis product, administration of high-dose pretransplant conditioning therapy, and finally infusion of the cryopreserved stem cells after thawing. However, in cancer centers that treat patients with multiple myeloma and have transplantation capabilities but lack or are in the process of acquiring cryopreservation facilities, alternatively noncryopreserved autologous stem cell therapy has been performed with remarkable success as the pretransplant conditioning therapy is usually brief.
摘要
大剂量化疗后进行自体造血干细胞移植被认为是适合移植的多发性骨髓瘤患者的标准治疗方法。自体移植过程包括以下步骤：通过使用特定的诱导治疗方案控制原发性疾病、动员干细胞、通过单采术采集动员的干细胞、对单采产物进行冷冻保存、给予大剂量移植前预处理治疗，最后在解冻后输注冷冻保存的干细胞。然而，在治疗多发性骨髓瘤患者且具备移植能力但缺乏或正在购置冷冻保存设施的癌症中心，由于移植前预处理治疗通常较为简短，非冷冻保存的自体干细胞治疗也取得了显著成功。
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本文引用的文献
1
Genetic markers used for risk stratification in multiple myeloma.用于多发性骨髓瘤风险分层的遗传标志物。
Genet Res Int. 2011;2011:798089. doi: 10.4061/2011/798089. Epub 2011 Sep 13.
2
Stem cell transplantation for multiple myeloma: current and future status.多发性骨髓瘤的干细胞移植：现状和未来。
Hematology Am Soc Hematol Educ Program. 2011;2011:191-6. doi: 10.1182/asheducation-2011.1.191.
3
Non-cryopreserved hematopoietic stem cell transplantation in multiple myeloma, a single center experience.非冷冻保存造血干细胞移植治疗多发性骨髓瘤：单中心经验
Clin Transplant. 2012 Jan-Feb;26(1):117-22. doi: 10.1111/j.1399-0012.2011.01432.x. Epub 2011 Sep 15.
4
Current trends in autologous stem-cell transplantation for myeloma in the era of novel therapies.新型疗法时代多发性骨髓瘤自体干细胞移植的现状。
J Clin Oncol. 2011 May 10;29(14):1898-906. doi: 10.1200/JCO.2010.32.5878. Epub 2011 Apr 11.
5
Long-term prognostic significance of response in multiple myeloma after stem cell transplantation.干细胞移植后多发性骨髓瘤反应的长期预后意义。
Blood. 2011 Jul 21;118(3):529-34. doi: 10.1182/blood-2011-01-332320. Epub 2011 Apr 11.
6
International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation.国际骨髓瘤工作组共识方法治疗适合自体干细胞移植的多发性骨髓瘤患者。
Blood. 2011 Jun 9;117(23):6063-73. doi: 10.1182/blood-2011-02-297325. Epub 2011 Mar 29.
7
Ultra high-risk myeloma.超高危骨髓瘤。
Hematology Am Soc Hematol Educ Program. 2010;2010:489-93. doi: 10.1182/asheducation-2010.1.489.
8
Multiple myeloma: 2011 update on diagnosis, risk-stratification, and management.多发性骨髓瘤：2011 年诊断、风险分层和治疗进展。
Am J Hematol. 2011 Jan;86(1):57-65. doi: 10.1002/ajh.21913.
9
Gastrointestinal pathology of autologous graft-versus-host disease following hematopoietic stem cell transplantation: a clinicopathological study of 17 cases.自体造血干细胞移植后移植物抗宿主病的胃肠道病理学：17 例临床病理研究。
Mod Pathol. 2011 Jan;24(1):117-25. doi: 10.1038/modpathol.2010.163. Epub 2010 Oct 15.
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