轻度认知障碍中的执行功能障碍：亚型还是早期症状？
Executive Dysfunction in MCI: Subtype or Early Symptom.
作者信息
Reinvang Ivar, Grambaite Ramune, Espeseth Thomas
机构信息
Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0316 Oslo, Norway.
出版信息
Int J Alzheimers Dis. 2012;2012:936272. doi: 10.1155/2012/936272. Epub 2012 May 30.
Abstract
Mild cognitive impairment (MCI) may take several forms, and amnestic MCI (aMCI) has been recognized as an early stage of Alzheimer's Disease (AD). Impairment in executive functions including attention (eMCI) may be indicative of several neurodegenerative conditions. Executive impairment is frequently found in aMCI, it is significant for prognosis, and patients with eMCI may go on to develop AD. Recent studies have found changes in white matter integrity in patients with eMCI to be more sensitive than measures of cortical atrophy. Studies of genetic high-risk groups using sensitive cognitive neuroscience paradigms indicate that changes in executive function may be a cognitive marker useful for tracking development in an AD pathophysiological process.
摘要
轻度认知障碍（MCI）可能有多种形式，遗忘型MCI（aMCI）已被公认为阿尔茨海默病（AD）的早期阶段。包括注意力在内的执行功能受损（eMCI）可能提示多种神经退行性疾病。执行功能障碍在aMCI中经常出现，对预后具有重要意义，且eMCI患者可能会发展为AD。最近的研究发现，eMCI患者白质完整性的变化比皮质萎缩指标更敏感。使用敏感的认知神经科学范式对遗传高危人群的研究表明，执行功能的变化可能是用于追踪AD病理生理过程发展的有用认知标志物。
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