Kim Seong Jae, Lee Jung Hie, Jang Jae-Won, Jung Hee Seo, Suh In Bum
Department of Psychiatry, Chosun University College of Medicine, Gwangju, South Korea.
Department of Psychiatry, Chosun University Hospital, Gwangju, South Korea.
J Circadian Rhythms. 2023 Dec 28;21:4. doi: 10.5334/jcr.227. eCollection 2023.
We aimed to examine the difference in rest-activity rhythm (RAR) and light exposure rhythm (LER) between patients with mild cognitive impairment (MCI) and normal controls (NC), and to verify their relationships with cognitive functions. The neuropsychological battery was administered to participants above 50 years old. The MCI diagnosis was made according to Petersen's criteria. Ten patients with MCI (77.90 ± 6.95 years) and eight NC (74.75 ± 5.06 years) were studied. Actigraphy (Actiwatch 2; Philips Respironics) was recorded at home for 5 days. RAR and LER variables, including interdaily stability (IS), intradaily variability (IV) and relative amplitude, were calculated using nonparametric analyses. The associations between cognitive performance and RAR and LER variables were explored using generalized linear models. There were no significant differences in RAR or LER variables between MCI and NC. There was a significant main effect of RAR-IS on the Stroop Color and Word Test (SCWT), indicating a positive relationship between RAR stability and SCWT performance. There was a significant group by RAR-IS interaction on Trail Making Test-A, indicating a negative relationship in MCI compared to NC. There was a significant group by LER-IV interaction on the Boston Naming Test, indicating a positive relationship in MCI compared to NC. There was no disruption in RAR and LER in patients with MCI. Our study showed that circadian rhythm abnormality was associated with a decline in executive function. However, circadian rhythm abnormality was not associated with declines in processing speed and language function in patients with MCI, implying an altered pathophysiology compared to NC.
我们旨在研究轻度认知障碍（MCI）患者与正常对照组（NC）之间静息 - 活动节律（RAR）和光照暴露节律（LER）的差异，并验证它们与认知功能的关系。对50岁以上的参与者进行了神经心理成套测验。MCI诊断根据彼得森标准做出。研究了10例MCI患者（77.90±6.95岁）和8例NC（74.75±5.06岁）。在家中使用活动记录仪（Actiwatch 2；飞利浦伟康公司）记录5天。使用非参数分析计算RAR和LER变量，包括日间稳定性（IS）、日内变异性（IV）和相对振幅。使用广义线性模型探索认知表现与RAR和LER变量之间的关联。MCI组和NC组之间的RAR或LER变量没有显著差异。RAR - IS对斯特鲁普颜色和文字测验（SCWT）有显著的主效应，表明RAR稳定性与SCWT表现之间存在正相关。在连线测验A上，RAR - IS与组别存在显著交互作用，表明与NC相比，MCI组存在负相关。在波士顿命名测验上，LER - IV与组别存在显著交互作用，表明与NC相比，MCI组存在正相关。MCI患者的RAR和LER没有紊乱。我们的研究表明，昼夜节律异常与执行功能下降有关。然而，MCI患者的昼夜节律异常与处理速度和语言功能下降无关，这意味着与NC相比，其病理生理学有所改变。
