Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Org Lett. 2012 Jul 6;14(13):3237-9. doi: 10.1021/ol301240g. Epub 2012 Jun 13.
A method for efficient and aldehyde-selective Wacker oxidation of aryl-substituted olefins using PdCl(2)(MeCN)(2), 1,4-benzoquinone, and t-BuOH in air is described. Up to a 96% yield of aldehyde can be obtained, and up to 99% selectivity can be achieved with styrene-related substrates.
一种使用 PdCl2(MeCN)2、1,4-苯醌和 t-BuOH 在空气中高效且选择性地进行芳基取代烯烃的瓦克氧化的方法被描述。可以获得高达 96%的醛产率，并且对于苯乙烯相关的底物可以达到 99%的选择性。
