Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
J Clin Periodontol. 2012 Aug;39(8):725-35. doi: 10.1111/j.1600-051X.2012.01910.x. Epub 2012 Jun 13.
Periodontal disease negatively affects oral health-related quality of life (OHRQoL). While there is sufficient evidence for the clinical efficacy of periodontal therapy, data on patient-based outcomes are limited.
To systematically review the available evidence on the impact of periodontal therapy on OHRQoL in adults.
MATERIAL & METHODS: MEDLINE, EMBASE, CENTRAL and LILACS were searched without language restrictions. Longitudinal observational and intervention studies assessing changes in OHRQoL using validated measures, in adults with periodontal disease undergoing non-surgical (NST) or surgical therapy (ST), were eligible for inclusion. Study quality was assessed using the Newcastle-Ottawa scale and CONSORT-checklist. No meta-analysis was performed.
Eleven studies (seven prospective case-series', one controlled before-after study and three randomized controlled trials) of "medium" methodological quality were included in the review. All studies reported impaired OHRQoL before therapy. Nine studies reported a statistically significant improvement in OHRQoL after NST (follow-up = 1 week to 12 months, p < 0.05). The effect size for this improvement ranged from small (0.27) to large (0.8). No significant differences were reported between different forms of NST. Surgical therapy had a relatively lower impact on OHRQoL. A correlation between poor clinical response to therapy and poor OHRQoL outcomes was observed.
Routine non-surgical therapy can moderately improve the OHRQoL in adults with periodontal disease.
牙周病会对口腔健康相关生活质量（OHRQoL）产生负面影响。虽然牙周病治疗的临床疗效已有充分证据，但基于患者的结果数据有限。
系统回顾牙周病治疗对成年人 OHRQoL 的影响的现有证据。
检索 MEDLINE、EMBASE、CENTRAL 和 LILACS，不限制语言。纳入使用经过验证的措施评估牙周病成年人在接受非手术（NST）或手术治疗（ST）后 OHRQoL 变化的纵向观察性和干预性研究。使用纽卡斯尔-渥太华量表和 CONSORT 清单评估研究质量。未进行荟萃分析。
纳入了 11 项研究（7 项前瞻性病例系列研究、1 项对照前后研究和 3 项随机对照试验），这些研究的方法学质量为“中等”。所有研究均报告治疗前 OHRQoL 受损。9 项研究报告 NST 后 OHRQoL 有统计学显著改善（随访时间为 1 周到 12 个月，p<0.05）。改善的效应大小范围从小（0.27）到中到大（0.8）。不同形式的 NST 之间未报告有显著差异。手术治疗对 OHRQoL 的影响相对较小。观察到治疗临床反应差与 OHRQoL 结果差之间存在相关性。
常规非手术治疗可以适度改善牙周病成年人的 OHRQoL。
