用于评估宫颈环扎术后早产风险的胎儿纤连蛋白检测
Fetal fibronectin for evaluation of preterm labor in the setting of cervical cerclage.
作者信息
Benson James E, Landy Helain J, Ghidini Alessandro, Drassinower Daphnie, Poggi Sarah H
机构信息
Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC 20007, USA.
出版信息
J Matern Fetal Neonatal Med. 2012 Nov;25(11):2330-2. doi: 10.3109/14767058.2012.695820. Epub 2012 Jun 19.
OBJECTIVE
To evaluate the efficacy of fetal fibronectin (fFN) testing in cervical cerclage patients presenting with acute signs or symptoms of preterm labor.
METHODS
A total of 71 fFN tests were performed in 48 women between 23 and 34 weeks' gestation who presented at two institutions at risk for imminent delivery with cerclage in situ.
RESULTS
The sensitivity, specificity, positive predictive value, and negative predictive value for delivery within 2 weeks of fFN testing were 100, 77, 28 and 100%, respectively. For delivery before 34 weeks sensitivity, specificity, positive predictive value, and negative predictive value were 91, 78, 56 and 97%, respectively. The relative risk of delivery <34 weeks with positive fFN was 16.7 (P < 0.001).
CONCLUSIONS
For patients with cervical cerclage, fFN testing is a valid diagnostic tool in the evaluation of preterm labor.
目的
评估胎儿纤连蛋白（fFN）检测在出现早产急性体征或症状的宫颈环扎术患者中的疗效。
方法
对48名妊娠23至34周的女性进行了总共71次fFN检测，这些女性在两家有紧急分娩风险且宫颈环扎术在位的机构就诊。
结果
fFN检测后2周内分娩的敏感性、特异性、阳性预测值和阴性预测值分别为100%、77%、28%和100%。在34周前分娩的敏感性、特异性、阳性预测值和阴性预测值分别为91%、78%、56%和97%。fFN阳性时34周前分娩的相对风险为16.7（P < 0.001）。
结论
对于宫颈环扎术患者，fFN检测是评估早产的有效诊断工具。
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