迷走神经刺激可阻断烧伤后局部和远处部位的血管通透性。
Vagus nerve stimulation blocks vascular permeability following burn in both local and distal sites.
机构信息
Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, MC 8236, 212 Dickinson Street, San Diego, CA 92103, USA.
出版信息
Burns. 2013 Feb;39(1):68-75. doi: 10.1016/j.burns.2012.04.004. Epub 2012 Jun 12.
Recent studies have shown that vagus nerve stimulation (VNS) can block the burn-induced systemic inflammatory response (SIRS). In this study we examined the potential for VNS to modulate vascular permeability (VP) in local sites (i.e. skin) and in secondary sites (i.e. lung) following burn. In a 30% total body surface area burn model, VP was measured using intravascular fluorescent dextran for quantification of the VP response in skin and lung. A peak in VP of the skin was observed 24h post-burn injury, that was blocked by VNS. Moreover, in the lung, VNS led to a reduction in burn-induced VP compared to sham-treated animals subjected to burn alone. The protective effects of VNS in this model were independent of the spleen, suggesting that the spleen was not a direct mediator of VNS. These studies identify a role for VNS in the regulation of VP in burns, with the translational potential of attenuating lung complications following burn.
最近的研究表明，迷走神经刺激（VNS）可以阻断烧伤引起的全身炎症反应（SIRS）。在这项研究中，我们研究了 VNS 调节烧伤后局部部位（即皮肤）和继发性部位（即肺）血管通透性（VP）的潜力。在 30%的全身体表面积烧伤模型中，使用血管内荧光右旋糖酐测量 VP，以定量测量皮肤和肺中的 VP 反应。烧伤后 24 小时观察到皮肤 VP 峰值，VNS 可阻断该峰值。此外，在肺中，与单独烧伤的假处理动物相比，VNS 导致烧伤诱导的 VP 减少。VNS 在该模型中的保护作用与脾脏无关，表明脾脏不是 VNS 的直接介导者。这些研究确定了 VNS 在烧伤时调节 VP 的作用，具有减轻烧伤后肺部并发症的转化潜力。
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