Llorente José Luis, López Fernando, Suárez Vanessa, Costales María, Moreno Carla, Suárez Carlos
Unidad de Base de Cráneo, Servicio de Otorrinolaringología, Instituto Universitario de Oncología del Principado de Asturias, Hospital Universitario Central de Asturias, Oviedo, España.
Acta Otorrinolaringol Esp. 2012 Nov-Dec;63(6):413-20. doi: 10.1016/j.otorri.2012.04.004. Epub 2012 Jun 12.
Anterior craniofacial resection (CFR) is a standardised procedure for the treatment of tumours involving the anterior skull base. We present our experience in the endoscopic treatment of these tumours.
A retrospective analysis was performed of patients treated by endoscopic anterior CFR in our Department from 2004 until 2011.
Thirty-two patients were analysed. Mean follow-up was 28 months (range: 6-84 months). The most frequent pathological entity was adenocarcinoma (60%), followed by undifferentiated carcinoma (13%). According to TNM classification, malignant epithelial tumour staging was T3 in 9%, T4a in 53% and T4b in 19% of the malignant epithelial tumours. The complication rate was 6% and the resection was complete in 91% of cases. During follow-up, 9% of patients developed recurrence. The 5-year overall survival rate was 70% and the 5-year disease-free survival rate was 85%
These results seem to indicate that properly planned endoscopic CFR may be a valid alternative to traditional open approaches for the management of malignancies of the anterior skull base.
前颅底切除术（CFR）是治疗累及前颅底肿瘤的标准化手术。我们介绍我们在内镜治疗这些肿瘤方面的经验。
对2004年至2011年在我科接受内镜下前颅底切除术治疗的患者进行回顾性分析。
分析了32例患者。平均随访28个月（范围：6 - 84个月）。最常见的病理类型是腺癌（60%），其次是未分化癌（13%）。根据TNM分类，恶性上皮性肿瘤分期为T3的占9%，T4a的占53%，T4b的占19%。并发症发生率为6%，91%的病例切除完整。随访期间，9%的患者出现复发。5年总生存率为70%，5年无病生存率为85%。
这些结果似乎表明，精心规划的内镜下前颅底切除术可能是治疗前颅底恶性肿瘤的传统开放手术的有效替代方法。
