Tripathi K K, Madhusudana S N, Sahu A
Central Research Institute, Kasauli.
Indian J Med Res. 1990 Sep;91:334-9.
There exist two different immunization schedules for neural tissue rabies vaccine (NTV) for human use in India, the amount of vaccine given by the schedule recommended by Central Research Institute (CRI), Kasauli, being higher than that recommended by Pasteur Institute of India (PII), Coonoor. A study was therefore undertaken to assess the feasibility of reducing the CRI dosage schedule for rabies prophylaxis. The antirabies antibody response in laboratory animals and human subjects following 7, 10 and 14 daily doses of NTV with or without administering rabies immune globulin (RIG) was much higher than the minimum protective level of 0.5 IU/ml of serum. Based on these results, the CRI schedule could be reduced from 14 x 5 ml of NTV to 10 x 5 ml in class II and class III rabies exposure cases.
在印度，用于人类的神经组织狂犬病疫苗（NTV）有两种不同的免疫接种方案，卡萨勒中央研究所（CRI）推荐方案所使用的疫苗剂量高于印度库努尔巴斯德研究所（PII）推荐的剂量。因此开展了一项研究，以评估减少CRI狂犬病预防剂量方案的可行性。在实验室动物和人类受试者中，每日接种7、10和14剂NTV（无论是否同时注射狂犬病免疫球蛋白（RIG））后的抗狂犬病抗体反应远高于血清最低保护水平0.5 IU/ml。基于这些结果，在II级和III级狂犬病暴露病例中，CRI方案可从14×5ml NTV减少至10×5ml。
