Second Department of Surgery, Aretaieion Hospital, School of Medicine, University of Athens, Athens, Greece.
Pancreas. 2012 Jul;41(5):671-7. doi: 10.1097/MPA.0b013e31823c9d21.
MicroRNAs are molecules implicated in RNA-RNA interaction, playing a role in cell proliferation and differentiation, as well as in carcinogenesis. Knowledge on their biological features is necessary to understand their role in phenotypic characteristics of pancreatic adenocarcinoma.
Review of current literature concerning mechanisms of action, studying methods, implementations, and preclinical trials on pancreatic adenocarcinoma.
More than 20 microRNAs have been identified, being involved in pancreatic adenocarcinoma biology, affecting tumor growth, metastatic potential, and chemosensitivity. Combinations of microRNAs can be used to differentiate between pancreatic adenocarcinoma and other pancreatic pathologies, as well as to assess prognosis. Manipulations of microRNAs can decrease the rate of growth or reinstall chemosensitivity to certain chemotherapeutic agents.
The field of microRNAs promises novel diagnostic and therapeutic tools in the management of pancreatic adenocarcinoma.
microRNAs 是一种参与 RNA-RNA 相互作用的分子，在细胞增殖和分化以及致癌过程中发挥作用。了解其生物学特征对于理解其在胰腺腺癌表型特征中的作用是必要的。
综述有关胰腺腺癌作用机制、研究方法、实施情况和临床前试验的当前文献。
已经鉴定出 20 多种 microRNAs，它们参与胰腺腺癌生物学，影响肿瘤生长、转移潜力和化学敏感性。microRNAs 的组合可用于区分胰腺腺癌和其他胰腺疾病，并评估预后。microRNAs 的操作可以降低某些化疗药物的生长速度或重新安装化学敏感性。
microRNAs 领域有望为胰腺腺癌的治疗提供新的诊断和治疗工具。
