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Exploring protein kinase inhibitors: unveiling gemcitabine resistance in pancreatic cancer.

作者信息

Kim Yeon Jeong, Hong Young Bin, Cho Chi Heum, Seong Yeon-Sun, Bae Insoo

出版信息

Pancreas. 2012 Jul;41(5):804-5. doi: 10.1097/MPA.0b013e31823f3fcb.

DOI:10.1097/MPA.0b013e31823f3fcb
PMID:22695089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3375494/
Abstract
摘要

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Exploring protein kinase inhibitors: unveiling gemcitabine resistance in pancreatic cancer.探索蛋白激酶抑制剂：揭示胰腺癌中的吉西他滨耐药性。
Pancreas. 2012 Jul;41(5):804-5. doi: 10.1097/MPA.0b013e31823f3fcb.
2
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Oncotarget. 2015 Sep 22;6(28):26230-41. doi: 10.18632/oncotarget.4579.
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Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape.细胞内KRAS特异性抗体通过诱导内体逃逸增强吉西他滨在胰腺癌中的抗肿瘤疗效。
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本文引用的文献

1
Exploring protein kinase inhibitors: potentiating gemcitabine efficacy in pancreatic cancer.探索蛋白激酶抑制剂：增强吉西他滨在胰腺癌中的疗效
Pancreas. 2012 Apr;41(3):496-8. doi: 10.1097/MPA.0b013e318230f71a.
2
Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer.极光 B 激酶抑制剂 AZD1152：作用决定因素及增强胰腺癌和结肠癌化疗效果的能力。
Br J Cancer. 2011 Mar 1;104(5):769-80. doi: 10.1038/bjc.2011.21. Epub 2011 Feb 8.
3
Disrupted plasma membrane localization of equilibrative nucleoside transporter 2 in the chemoresistance of human pancreatic cells to gemcitabine (dFdCyd).
癌症及癌症干细胞中的ATM、ATR、CHK1、CHK2和WEE1抑制剂
Medchemcomm. 2016 Nov 30;8(2):295-319. doi: 10.1039/c6md00439c. eCollection 2017 Feb 1.
4
Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells.达沙替尼与吉西他滨联合使用可降低ALDH1A1的表达，并抑制吉西他滨耐药的胰腺癌MIA PaCa-2细胞的增殖。
Int J Oncol. 2014 Jun;44(6):2132-8. doi: 10.3892/ijo.2014.2357. Epub 2014 Mar 21.
5
Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine.抑制检查点激酶 2（CHK2）可增强胰腺腺癌细胞对吉西他滨的敏感性。
J Cell Mol Med. 2013 Oct;17(10):1261-70. doi: 10.1111/jcmm.12101. Epub 2013 Jul 16.
在吉西他滨（dFdCyd）耐药的人胰腺细胞中，核苷转运蛋白 2 的质膜定位被打乱。
Cancer Sci. 2011 Mar;102(3):622-9. doi: 10.1111/j.1349-7006.2010.01837.x. Epub 2011 Jan 20.
4
Pancreatic cancer.胰腺癌
N Engl J Med. 2010 Apr 29;362(17):1605-17. doi: 10.1056/NEJMra0901557.
5
Cell cycle kinases as therapeutic targets for cancer.细胞周期激酶作为癌症的治疗靶点。
Nat Rev Drug Discov. 2009 Jul;8(7):547-66. doi: 10.1038/nrd2907.
6
Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.合成致死性RNA干扰筛选确定胰腺癌中吉西他滨治疗的增敏靶点。
J Transl Med. 2009 Jun 11;7:43. doi: 10.1186/1479-5876-7-43.
7
Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy.糖原合酶激酶-3抑制可破坏胰腺癌中的核因子-κB活性，但未能使胰腺癌对吉西他滨化疗敏感。
BMC Cancer. 2009 Apr 30;9:132. doi: 10.1186/1471-2407-9-132.
8
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.药物联合研究中协同作用和拮抗作用的理论基础、实验设计及计算机模拟
Pharmacol Rev. 2006 Sep;58(3):621-81. doi: 10.1124/pr.58.3.10.
9
Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells.抑制SRC酪氨酸激酶可损害人胰腺腺癌细胞对吉西他滨的固有耐药性和获得性耐药性。
Clin Cancer Res. 2004 Apr 1;10(7):2307-18. doi: 10.1158/1078-0432.ccr-1183-3.
10
Incidence, mechanism and prognostic value of activated AKT in pancreas cancer.胰腺癌中活化型AKT的发生率、机制及预后价值
Br J Cancer. 2003 Dec 1;89(11):2110-5. doi: 10.1038/sj.bjc.6601396.