The Egyptian IVF Center, Maadi, Cairo, Egypt; Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Reprod Biomed Online. 2012 Aug;25(2):133-8. doi: 10.1016/j.rbmo.2012.03.013. Epub 2012 Apr 3.
The aim of this study was to evaluate the effect of vaginal natural progesterone on the prevention of preterm birth in IVF/intracytoplasmic sperm injection (ICSI) pregnancies. A single-centre prospective placebo-controlled randomized study was performed. A total of 313 IVF/ICSI pregnant patients were randomized into two groups for either treatment with daily 400 mg vaginal natural progesterone or placebo, starting from mid-trimester up to 37 weeks or delivery. Amongst the patients, there were 215 singleton and 91 twin pregnancies. There was no significant difference in risk of preterm birth among all patients (OR 0.672, 95% CI 0.42-1.0. There was a significantly lower preterm birth rate in singleton pregnancies in the natural progesterone arm (OR 0.53, 95% CI 0.28-0.97) and no significant difference between both arms in twin pregnancies (OR 0.735, 95% CI 0.36-2). In conclusion, the administration of 400 mg vaginal natural progesterone from mid trimester reduced the incidence of preterm birth in singleton, but not in twin, IVF/ICSI pregnancies.
本研究旨在评估阴道天然黄体酮对体外受精/胞浆内单精子注射（ICSI）妊娠中早产的预防作用。进行了一项单中心前瞻性安慰剂对照随机研究。共有 313 名 IVF/ICSI 妊娠患者随机分为两组，一组每天接受 400mg 阴道天然黄体酮治疗，另一组给予安慰剂，从中孕期持续到 37 周或分娩。患者中，有 215 例单胎妊娠和 91 例双胎妊娠。所有患者的早产风险无显著差异（OR 0.672，95%CI 0.42-1.0. 天然黄体酮组的单胎妊娠早产率显著降低（OR 0.53，95%CI 0.28-0.97），而双胎妊娠两组之间无显著差异（OR 0.735，95%CI 0.36-2）。总之，从中孕期开始每天给予 400mg 阴道天然黄体酮可降低单胎 IVF/ICSI 妊娠的早产发生率，但对双胎妊娠无影响。
