Ali Mohammed K, McKeever Bullard Kai, Imperatore Giuseppina, Barker Lawrence, Gregg Edward W
Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, CDC, 4770 Buford Hwy NE, Atlanta, GA 30341, USA.
MMWR Suppl. 2012 Jun 15;61(2):32-7.
Nationally representative estimates indicate that 18.8 million adults in the United States have received a diagnosis with diabetes mellitus. When glycemic control is not optimized, diabetes imposes additional burdensome care requirements, health-care costs, and high risk of disabling complications, and this has been especially evident in socioeconomically disadvantaged and minority populations. For example, higher levels of glycated hemoglobin (A1c) have been associated with increased risk of diabetic retinopathy, increased risk of chronic kidney disease, and increased risk of cardiovascular disease. Reducing A1c levels through combined clinical and effective self-management has demonstrated reduced risk for microvascular complications. Although the most appropriate target A1c levels to achieve optimal health impact might vary among persons, the majority of adults with diabetes will benefit from reduction of A1c levels to ≤7%; targets for patients with a history of severe hypoglycemia, or with limited life expectancy, or with advanced complications, or with certain comorbid conditions might be higher. Nevertheless, an A1c level of 9% constitutes a clearly modifiable, high level of risk that few, if any, persons with diabetes should be exposed to. Accordingly, the Healthy People 2020 objectives include a 10% reduction in the proportion of the diabetes population that has poor glycemic control (A1c >9%) as a target.
全国代表性估计数据表明,美国有1880万成年人被诊断患有糖尿病。当血糖控制未达到最佳状态时,糖尿病会带来额外繁重的护理需求、医疗成本以及出现致残并发症的高风险,这在社会经济地位不利和少数族裔人群中尤为明显。例如,糖化血红蛋白(A1c)水平升高与糖尿病视网膜病变风险增加、慢性肾病风险增加以及心血管疾病风险增加相关。通过联合临床和有效的自我管理来降低A1c水平已证明可降低微血管并发症的风险。尽管实现最佳健康影响的最合适目标A1c水平可能因人而异,但大多数糖尿病成年人将受益于将A1c水平降至≤7%;对于有严重低血糖史、预期寿命有限、有晚期并发症或有某些合并症的患者,目标水平可能更高。然而,9%的A1c水平构成了一个明显可改变的高风险水平,几乎没有糖尿病患者应该处于这个水平。因此,《健康人民2020》的目标包括将血糖控制不佳(A1c>9%)的糖尿病患者比例降低10%作为目标。