Department of Radiology, Zhongshan Hospital of Fudan University and Department of Medical Image, Shanghai Medical College of Fudan University, No. 138, Fenglin Road, Xuhui District, Shanghai 200032, China.
Eur J Radiol. 2012 Aug;81(8):e917-22. doi: 10.1016/j.ejrad.2012.05.011. Epub 2012 Jun 12.
To investigate the microcirculation in pancreatic cancer by pharmacokinetic analysis of multiple breath-hold dynamic contrast-enhanced magnetic resonance imaging at 3.0T.
Multiple breath-hold dynamic contrast-enhanced magnetic resonance imaging was performed in 40 healthy volunteers and 40 patients with pancreatic cancer proven by histopathology using an axial three-dimensions fat-saturated T1-weighted spoiled-gradient echo sequence at 3.0T. A two compartment model with T1 correction was used to quantify the transfer constant, the rate constant of backflux from the extravascular extracellular space to the plasma and the extravascular extracellular space fractional volume in pancreatic cancer, obstructive pancreatitis distal to the malignant tumor, adjacent pancreatic tissue proximal to the tumor and normal pancreas. All parameters were statistically analyzed.
Statistical differences were noticed in both the transfer constant (p=0.000075) and the rate constant of backflux (p=0.006) among different tissues. Both the transfer constant and the rate constant of backflux in pancreatic cancer were statistically lower than those in normal pancreas and adjacent pancreatic tissue (p<0.05). Both the transfer constant and the rate constant of backflux in obstructive pancreatitis were statistically lower than those in normal pancreas and adjacent pancreatic tissue (p<0.05). The extravascular extracellular space fractional volume in pancreatic cancer was statistically lager than that in normal pancreas (p=0.002).
Multiple breath-hold dynamic contrast-enhanced magnetic resonance imaging offers a useful technique to evaluate the microenvironment in pancreatic cancer at 3.0T. Compared to normal pancreas, pancreatic cancer has lower transfer constant, rate constant of backflux and larger extravascular extracellular space fractional volume.
通过 3.0T 多屏气动态对比增强磁共振成像的药代动力学分析研究胰腺癌的微循环。
使用轴向三维脂肪饱和 T1 加权扰相梯度回波序列在 3.0T 对 40 名经组织病理学证实的胰腺癌患者和 40 名健康志愿者进行多屏气动态对比增强磁共振成像。采用双室模型结合 T1 校正来定量评估胰腺癌、肿瘤远端阻塞性胰腺炎、肿瘤近端胰腺组织和正常胰腺的转移常数、血管外细胞外空间向血浆回流的速率常数和血管外细胞外空间分容积。对所有参数进行统计学分析。
不同组织间的转移常数（p=0.000075）和回流速率常数（p=0.006）均存在统计学差异。胰腺癌的转移常数和回流速率常数均明显低于正常胰腺和肿瘤近端胰腺组织（p<0.05）。阻塞性胰腺炎的转移常数和回流速率常数均明显低于正常胰腺和肿瘤近端胰腺组织（p<0.05）。胰腺癌的血管外细胞外空间分容积明显大于正常胰腺（p=0.002）。
多屏气动态对比增强磁共振成像在 3.0T 条件下为评估胰腺癌的微环境提供了一种有用的技术。与正常胰腺相比，胰腺癌的转移常数、回流速率常数较低，血管外细胞外空间分容积较大。
