Boozer C N, Choban P S, Atkinson R L
Department of Internal Medicine, Eastern Virginia Medical School, Norfolk.
Int J Obes. 1990 Oct;14(10):869-78.
High-fat diets enhance weight gain in rats and humans. Ileal transposition surgery (IT) causes long-term weight loss on ad libitum food intake. This study was designed to study the effect of high-fat diets on weight loss following ileal transposition surgery. We weight matched 40 rats, performed IT or sham IT, and fed defined high-carbohydrate (12 percent kcal as fat) or high-fat (45 percent kcal as fat) diets for 15 weeks postsurgery (N = 10/group, data are means +/- s.e.m.). Overall, IT rats ate less than sham IT rats, 9587 +/- 304 v. 10,615 +/- 356 kcal (39.6 +/- 1.2 v. 43.8 +/- 1.5 MJ) (P less than 0.01), and gained less weight (-14 +/- 7.8 v. 46 +/- 13.7 g) (P less than 0.01). Sham IT rats had similar food intakes on the two diets, but body weights were increased on the high-fat diet. However, the IT rats on the high-fat diet did not gain more weight or have higher efficiency of weight gain than did the IT rats on the high-carbohydrate diet. We conclude that ileal transposition attenuates the increased efficiency of weight gain usually associated with consumption of a high-fat diet. The mechanisms of this decreased metabolic efficiency are unclear.
高脂饮食会增加大鼠和人类的体重。回肠转位手术（IT）可使大鼠在随意进食的情况下长期减重。本研究旨在探讨高脂饮食对回肠转位手术后体重减轻的影响。我们将40只大鼠按体重匹配，进行IT手术或假手术，并在术后15周给予特定的高碳水化合物（脂肪供能占12%千卡）或高脂（脂肪供能占45%千卡）饮食（每组N = 10只，数据为均值±标准误）。总体而言，IT大鼠的食量小于假手术大鼠，分别为9587±304千卡对10615±356千卡（39.6±1.2兆焦对43.8±1.5兆焦）（P<0.01），体重增加也较少（-14±7.8克对46±13.7克）（P<0.01）。假手术大鼠在两种饮食条件下的食量相似，但高脂饮食组体重增加。然而，高脂饮食组的IT大鼠与高碳水化合物饮食组的IT大鼠相比，体重增加并不更多，体重增加效率也不更高。我们得出结论，回肠转位可减弱通常与高脂饮食摄入相关的体重增加效率的提高。这种代谢效率降低的机制尚不清楚。
