卡替洛尔滴眼剂对原发性开角型青光眼患者视网膜动脉血流的影响。

Effects of topical carteolol on retinal arterial blood flow in primary open-angle glaucoma patients.

机构信息

Department of Ophthalmology, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa 078-8510, Japan.

出版信息

Jpn J Ophthalmol. 2012 Sep;56(5):458-63. doi: 10.1007/s10384-012-0156-1. Epub 2012 Jun 14.

DOI:10.1007/s10384-012-0156-1

PMID:22695833

Abstract

PURPOSE

Our aim was to evaluate the effects of topical carteolol on retinal arterial blood flow (RBF) in patients with primary open-angle glaucoma.

METHODS

Sixteen patients received carteolol topically for 90 days. Changes in RBF in the major retinal artery were evaluated using laser Doppler velocimetry at baseline and after 30, 60, and 90 days. Patients were divided into groups based on changes in RBF; retinal arterial blood column diameter, blood velocity, and ocular perfusion pressure (OPP) were compared.

RESULTS

Overall, no significant changes in RBF were observed. Twelve patients had unchanged and four decreased RBF. In patients with unchanged RBF, no significant changes in diameter, velocity, and OPP were observed. In patients with decreased RBF, the diameter did not change significantly; velocity decreased from baseline on day 90 (p = 0.041); OPP did not change significantly, but the values on days 30, 60, and 90 were lower than in patients with unchanged RBF.

CONCLUSIONS

Although carteolol preserved RBF, some patients had decreased RBF with low blood pressure, suggesting that carteolol decreases RBF in some patients with decreased ocular perfusion after the topical instillation of carteolol.

摘要

目的

评估卡替洛尔滴眼对原发性开角型青光眼患者视网膜动脉血流（RBF）的影响。

方法

16 例患者接受卡替洛尔滴眼治疗 90 天。采用激光多普勒流速仪在基线及治疗后 30、60 和 90 天评估主要视网膜动脉的 RBF 变化。根据 RBF 的变化将患者分为两组；比较视网膜动脉血柱直径、血流速度和眼灌注压（OPP）。

结果

总体而言，RBF 无明显变化。12 例患者 RBF 不变，4 例 RBF 下降。在 RBF 不变的患者中，直径、速度和 OPP 均无明显变化。在 RBF 下降的患者中，直径无明显变化；第 90 天的速度较基线下降（p = 0.041）；OPP 无明显变化，但 30、60 和 90 天的数值低于 RBF 不变的患者。