Sandyk R
Department of Clinical Neuropsychiatry, New York State Psychiatric Institute, NY 10032.
Int J Neurosci. 1990 Jan;50(1-2):37-53. doi: 10.3109/00207459008987155.
Barbeau hypothesized that Parkinson's disease is associated with hypothalamic deficiency of the specialized neuroendocrine cell system (A.P.U.D.) and that the degeneration of brainstem monoaminergic neurons is secondary to progressive functional loss of this cell system in the disease. The pineal gland meets criteria of the A.P.U.D. cell system and it is possible that dysfunction of the pineal gland may be associated with the pathophysiology and clinical manifestations of Parkinson's disease. Since the role of pineal melatonin in humans remains enigamatic, it is currently unclear which of the symptoms of Parkinson's disease may be associated with deregulation of the secretory activity of pineal melatonin. This review summarizes evidence linking possible alterations of pineal melatonin functions with the clinical manifestations of Parkinson's disease.
巴博提出假说，认为帕金森病与特殊神经内分泌细胞系统（胺前体摄取与脱羧细胞系统）的下丘脑功能缺陷有关，且脑干单胺能神经元的变性是该疾病中此细胞系统进行性功能丧失的继发结果。松果体符合胺前体摄取与脱羧细胞系统的标准，松果体功能障碍可能与帕金森病的病理生理学及临床表现相关。由于松果体褪黑素在人类中的作用仍不明确，目前尚不清楚帕金森病的哪些症状可能与松果体褪黑素分泌活动失调有关。本综述总结了将松果体褪黑素功能的可能改变与帕金森病临床表现相联系的证据。
