Sandyk R
Department of Clinical Neuropsychiatry, New York State Psychiatric Institute, NY 10032.
Int J Neurosci. 1990 Jan;50(1-2):83-94. doi: 10.3109/00207459008987159.
Recent clinical studies have suggested that electroconvulsive therapy (ECT) may be efficacious in the therapy of Parkinson's disease (PD). However, the mechanisms of action of ECT in PD are largely unknown. PD may be associated with reduction in the secretory activity of pineal melatonin, and the therapeutic efficacy of ECT in PD may be associated with an effect on the secretory activity of pineal melatonin. Further studies involving analysis of plasma melatonin levels and circadian release prior to and following ECT are needed more precisely to determine the role of pineal melatonin in PD and in the therapeutic efficacy of ETC in PD.
近期临床研究表明，电休克疗法（ECT）可能对帕金森病（PD）的治疗有效。然而，ECT治疗PD的作用机制在很大程度上尚不清楚。PD可能与松果体褪黑素分泌活性降低有关，ECT治疗PD的疗效可能与对松果体褪黑素分泌活性的影响有关。需要进一步开展研究，分析ECT治疗前后血浆褪黑素水平和昼夜节律释放情况，以更精确地确定松果体褪黑素在PD及ECT治疗PD疗效中的作用。
