Department of Medical Oncology, Eskişehir Osmangazi University Medical School, Eskisehir, Turkey.
Med Oncol. 2012 Dec;29(5):3125-8. doi: 10.1007/s12032-012-0274-0. Epub 2012 Jun 14.
The aim of this study was to evaluate coagulation disorders in patients with metastatic colorectal cancer treated with bevacizumab by using rotation thrombelastogram (ROTEM(®)) and correlate ROTEM(®) parameters with routine coagulation tests. A total of 18 colorectal cancer patients who received bevacizumab combined with chemotherapy were included. There was no statistically significant difference between results of platelet count, prothrombin time (PT) and activated partial thromboplastin time (APTT), fibrinogen, and D-Dimer obtained at baseline and on day 1 of chemotherapy cycles 4, 8, and 12. CFT value was significantly increased on day 1 of cycle 12 compared with baseline value by both INTEM and EXTEM assays while CT and MCF showed no significant difference. Correlation analysis revealed significant correlation between laboratory parameters and ROTEM(®) parameters. Platelet count showed a positive correlation with MCF in INTEM (r = 0.627) and EXTEM (r = 0.699) assays while showed a negative correlation with CFT in EXTEM (r = -603). There was a significant negative correlation between fibrinogen levels and CFT in INTEM (r = -0.617) and EXTEM (r = -0.512). Our data demonstrated the value of TEG over conventional coagulation tests in evaluating antiangiogenesis agents-induced coagulation disorders.
本研究旨在通过旋转血栓弹性描记法（ROTEM(®)）评估贝伐珠单抗治疗转移性结直肠癌患者的凝血障碍，并将 ROTEM(®)参数与常规凝血试验相关联。共纳入 18 例接受贝伐珠单抗联合化疗的结直肠癌患者。血小板计数、凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）、纤维蛋白原和 D-二聚体在基线和化疗周期第 4、8 和 12 天第 1 天的结果之间无统计学差异。与基线值相比，CFT 值在第 12 个周期的第 1 天通过 INTEM 和 EXTEM 检测均显著增加，而 CT 和 MCF 无显著差异。相关性分析显示实验室参数与 ROTEM(®)参数之间存在显著相关性。血小板计数在 INTEM（r = 0.627）和 EXTEM（r = 0.699）检测中与 MCF 呈正相关，而在 EXTEM 中与 CFT 呈负相关（r = -603）。纤维蛋白原水平与 INTEM（r = -0.617）和 EXTEM（r = -0.512）中的 CFT 呈显著负相关。我们的数据表明，TEG 在评估抗血管生成药物诱导的凝血障碍方面优于常规凝血试验。
