Division of Rheumatology, Department of Internal Medicine, Korea University, Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea.
Mol Biol Rep. 2012 Aug;39(8):8505-11. doi: 10.1007/s11033-012-1705-x. Epub 2012 Jun 14.
The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to vasculitis. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across nine comparative studies containing 1,922 vasculitis patients and 11,505 normal control subjects. Meta-analysis showed no association between the T allele and vasculitis in all subjects [odds ratio (OR) 1.046, 95 % confidence interval (CI) 0.755-1.1.451, p = 0.786], and analysis after stratification by ethnicity indicated that the T allele was not associated with vasculitis in Europeans (OR 1.104, 95 % CI 0.798-1.528, p = 0.551). However, meta-analysis showed a significant association between the T allele and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) (OR 1.415, 95 % CI 1.228-1.630, p = 1.59 × 10(-6)) and Wegener's granulomatosis (WG) (OR 1.829, 95 % CI 1.377-2.431, p = 3.09 × 10(-5)). In addition, meta-analysis showed an association between the T allele and WG in ANCA-positive subjects (OR 2.042, 95 % CI 1.534-2.719, p = 1.02 × 10(-6)), but not in ANCA-negative WG patients (OR 0.595, 95 % CI 0.199-1.781, p = 0.353). This meta-analysis does not show that the PTPN22 C1858T polymorphism is associated with vasculitis susceptibility, but does show that this polymorphism is associated with susceptibility to AAV, WG, and ANCA status in WG.
本研究旨在确定功能性蛋白酪氨酸磷酸酶非受体 22（PTPN22）C1858T 多态性（rs2476601）是否与血管炎易感性相关。我们对 9 项包含 1922 例血管炎患者和 11505 例正常对照的研究进行了 PTPN22 C1858T 多态性的荟萃分析。荟萃分析显示，在所有受试者中，T 等位基因与血管炎无关[比值比（OR）1.046，95%置信区间（CI）0.755-1.1.451，p=0.786]，且按种族分层分析表明，T 等位基因与欧洲人血管炎无关[OR 1.104，95%CI 0.798-1.528，p=0.551]。然而，荟萃分析显示 T 等位基因与抗中性粒细胞胞质抗体（ANCA）相关性血管炎（AAV）[OR 1.415，95%CI 1.228-1.630，p=1.59×10(-6)]和韦格纳肉芽肿（WG）[OR 1.829，95%CI 1.377-2.431，p=3.09×10(-5)]之间存在显著关联。此外，荟萃分析显示 T 等位基因与 ANCA 阳性患者的 WG 之间存在关联[OR 2.042，95%CI 1.534-2.719，p=1.02×10(-6)]，但与 ANCA 阴性的 WG 患者无关[OR 0.595，95%CI 0.199-1.781，p=0.353]。本荟萃分析显示，PTPN22 C1858T 多态性与血管炎易感性无关，但与 AAV、WG 和 WG 中的 ANCA 状态易感性相关。
