用于癌症治疗中系统性 siRNA 递送的肿瘤归巢聚硅氧烷/乙二醇壳聚糖自交联纳米粒。
Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment.
机构信息
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea.
出版信息
Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7203-7. doi: 10.1002/anie.201201390. Epub 2012 Jun 13.
The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.
简而言之
巯基化壳聚糖通过电荷相互作用和自交联作用与聚合 siRNA 形成稳定的纳米颗粒（参见方案）。这种多 siRNA/壳聚糖纳米颗粒（psi-TGC）为 siRNA 的系统传递提供了足够的体内稳定性。psi-TGC 下调肿瘤蛋白导致肿瘤体积缩小和血管生成减少。
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