Pedersen Mette, McGlashan Julian
ENT, The Medical Center, Østergade 18, 3, Copenhagen, Denmark, 1100.
Cochrane Database Syst Rev. 2012 Jun 13;2012(6):CD001934. doi: 10.1002/14651858.CD001934.pub2.
This is an update of a Cochrane review first published in The Cochrane Library in Issue 2, 2001 and previously updated in 2007 and 2009.Vocal cord nodules are bilateral, benign, callous-like growths of the mid-portion of the membranous vocal folds. They are of variable size and are characterised histologically by thickening of the epithelium with a variable degree of inflammation in the underlying superficial lamina propria. They characteristically produce hoarseness, discomfort and an unstable voice when speaking or singing.
To assess the effectiveness of surgery versus non-surgical interventions for vocal cord nodules.
We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; BIOSIS Previews; Cambridge Scientific Abstracts; ISRCTN and additional sources for published and unpublished trials. The date of the most recent search was 9 April 2012.
Randomised and quasi-randomised trials comparing any surgical intervention for vocal cord nodules with non-surgical treatment or no treatment.
No suitable trials were identified.
No studies fulfilled the inclusion criteria.
AUTHORS' CONCLUSIONS: There is a need for high-quality randomised controlled trials to evaluate the effectiveness of surgical and non-surgical treatment of vocal cord nodules.
这是一篇Cochrane系统评价的更新版，该评价首次发表于《Cochrane图书馆》2001年第2期，此前于2007年和2009年进行过更新。声带小结是双侧的、良性的、类似胼胝的膜性声带中段生长物。它们大小不一，组织学特征为上皮增厚，其下方的浅层固有层有不同程度的炎症。其典型表现为说话或唱歌时声音嘶哑、不适且嗓音不稳定。
评估手术与非手术干预治疗声带小结的有效性。
我们检索了Cochrane耳、鼻、喉疾病组试验注册库；Cochrane对照试验中央注册库（CENTRAL）；PubMed；EMBASE；CINAHL；科学引文索引；生物学文摘数据库；剑桥科学文摘；国际标准随机对照试验编号注册库以及其他已发表和未发表试验的来源。最近一次检索日期为2012年4月9日。
比较任何声带小结手术干预与非手术治疗或不治疗的随机和半随机试验。
未识别出合适的试验。
无研究符合纳入标准。
需要高质量的随机对照试验来评估声带小结手术和非手术治疗的有效性。
