钯催化的 C-C 键顺序形成：2-取代和 2,3-二取代喹啉的有效组装。
Palladium-catalyzed sequential formation of C-C bonds: efficient assembly of 2-substituted and 2,3-disubstituted quinolines.
机构信息
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
出版信息
Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7292-6. doi: 10.1002/anie.201202412. Epub 2012 Jun 13.
PMID:22696502
Abstract
A series of substituted quinolines was prepared from arylamines, aldehydes, and terminal olefins (see scheme). The palladium-catalyzed sequential formation of C-C bonds proceeds smoothly with both electron-deficient and electron-rich olefins. When acrylic acid is used as terminal olefin, decarboxylation occurs to provide 2-substituted quinolines.
摘要
从芳胺、醛和末端烯烃（见方案）制备了一系列取代的喹啉。钯催化的 C-C 键的顺序形成顺利进行，无论是缺电子还是富电子的烯烃。当丙烯酸用作末端烯烃时，会发生脱羧反应，得到 2-取代的喹啉。
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