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钯催化的芳香醛、芳胺和末端烯烃在分子氧下的多组分环化反应:1,4-二氢吡啶的组装。

Palladium-assisted multicomponent cyclization of aromatic aldehydes, arylamines and terminal olefins under molecular oxygen: an assembly of 1,4-dihydropyridines.

机构信息

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, P. R. China.

出版信息

Org Biomol Chem. 2011 Aug 7;9(15):5358-61. doi: 10.1039/c1ob05440f. Epub 2011 Jun 17.

Abstract

The palladium-assisted one-pot three-component reactions of aldehydes, amines and olefins proceeded smoothly to give 2,6-unsubstituted 1,4-dihydropyridines (1,4-DHPs) using molecular oxygen as a sole oxidant. It also provides efficient Pd-catalyzed aerobic oxidation access to the anti-Markovnikov oxidative amination products of olefins from primary aromatic amines and alkenes. The method is atom-efficient, using cheap and easily available starting materials and an environmentally benign oxidant.

摘要

钯催化的醛、胺和烯烃的一锅法三组分反应在氧气作为唯一氧化剂的条件下顺利进行,得到 2,6-未取代的 1,4-二氢吡啶(1,4-DHPs)。该方法还提供了高效的钯催化有氧氧化途径,可从伯芳基胺和烯烃合成反马氏规则的烯烃氧化氨化产物。该方法原子经济性高,使用廉价易得的起始原料和环境友好的氧化剂。

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