Heymer Kelly-Jean, Wentzlaff-Eggebert Matthias, Mortimer Elissa, Wilson David P
Faculty of Medicine, The University of New South Wales, Sydney, NSW 2010, Australia.
Sex Health. 2012 Jul;9(3):220-6. doi: 10.1071/SH10148.
As financial constraints can be a barrier to accessing HIV antiretroviral therapy (ART), we argue for the removal of copayment requirements from HIV medications in South Australia.
Using a simple mathematical model informed by available behavioural and biological data and reflecting the HIV epidemiology in South Australia, we calculated the expected number of new HIV transmissions caused by persons who are not currently on ART compared with transmissions for people on ART. The extra financial investment required to cover the copayments to prevent an HIV infection was compared with the treatment costs saved due to averting HIV infections.
It was estimated that one HIV infection is prevented per year for every 31.4 persons (median, 24.0-42.7 interquartile range (IQR)) who receive treatment. By considering the incremental change in costs and outcomes of a change in program from the current status quo, it would cost the health sector $17860 per infection averted (median, $13651-24287 IQR) if ART is provided as a three-dose, three-drug combination without requirements for user-pay copayments.
The costs of removing copayment fees for ART are less than the costs of treating extra HIV infections that would result under current conditions. Removing the copayment requirement for HIV medication would be cost-effective from a governmental perspective.
由于经济限制可能成为获取艾滋病毒抗逆转录病毒疗法(ART)的障碍,我们主张取消南澳大利亚州艾滋病毒药物的自付费用要求。
利用一个简单的数学模型,该模型依据现有的行为和生物学数据构建,并反映南澳大利亚州的艾滋病毒流行病学情况,我们计算了目前未接受抗逆转录病毒治疗的人群所导致的新增艾滋病毒传播预期数量,并与接受抗逆转录病毒治疗的人群的传播数量进行比较。将为防止艾滋病毒感染而支付自付费用所需的额外财政投入,与因避免艾滋病毒感染而节省的治疗成本进行了比较。
据估计,每31.4名接受治疗的人每年可预防1例艾滋病毒感染(中位数为24.0 - 42.7,四分位间距(IQR))。通过考虑从当前现状改变项目时成本和结果的增量变化,如果以三剂量、三种药物组合的方式提供抗逆转录病毒治疗且无需患者支付自付费用,那么卫生部门每避免一例感染将花费17860美元(中位数为13651 - 24287美元,IQR)。
取消抗逆转录病毒治疗的自付费用成本低于在当前情况下治疗新增艾滋病毒感染的成本。从政府角度来看,取消艾滋病毒药物的自付费用要求具有成本效益。