Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, Oulu Center for Cell Matrix Research, University of Oulu, P.O. Box 5000, Oulu FIN-90014, Finland.
Dev Cell. 2012 Jun 12;22(6):1125-6. doi: 10.1016/j.devcel.2012.05.016.
In this issue of Developmental Cell, Barak et al. (2012) identify a critical role for Fgf9 and Fgf20 signaling in the nephron progenitors of the developing mammalian kidney. These Fgfs serve as survival and nephron-forming competence signals for purified Six2+ cells that represent the progenitors that normally go on to generate nephrons.
在本期《发育细胞》中，Barak 等人（2012 年）确定了 Fgf9 和 Fgf20 信号在发育中哺乳动物肾脏的肾祖细胞中的关键作用。这些 Fgfs 作为 Six2+细胞的存活和肾单位形成能力信号，Six2+细胞代表通常继续产生肾单位的祖细胞。
