Juste Ramon A
Department of Animal Health, NEIKER-Tecnalia, Berreaga, 1, 48160 Derio, Bizkaia, Spain.
Vet Immunol Immunopathol. 2012 Jul 15;148(1-2):190-6. doi: 10.1016/j.vetimm.2012.05.017. Epub 2012 May 24.
Classical causality models for infectious diseases have fulfilled an important role in the progress of medical sciences, however, new forms of association where weakly pathogenic agents cause widespread infections that mostly do not progress to disease, but that if they do so, cause protracted clinical courses where the host resources are exhausted fit better with the slow infection concept proposed over half a century ago. This model could show an infectious cause behind some diseases that have never fulfilled the conventional criteria. While new mechanisms of causation are defined, these diseases still need to be controlled to allow sustainable animal production. Here, I discuss the case of paratuberculosis control by vaccination as an example of the benefits of using a theoretically preventive treatment to modify the course of infection towards preventing clinical disease even though the infection itself might not be fully controlled.
经典的传染病因果关系模型在医学科学发展中发挥了重要作用，然而，新的关联形式，即弱致病性病原体引发广泛感染，大多数感染不会发展成疾病，但如果发展成疾病，则会导致病程迁延，宿主资源耗尽，这更符合半个多世纪前提出的慢感染概念。这种模型可以揭示一些从未满足传统标准的疾病背后的感染原因。虽然确定了新的致病机制，但仍需控制这些疾病以实现可持续的动物生产。在此，我以通过接种疫苗控制副结核病为例，讨论使用理论上的预防性治疗来改变感染进程以预防临床疾病的益处，尽管感染本身可能无法得到完全控制。
