沉默杀手：胰腺癌中的旁分泌免疫抑制。
Silencing the killers: paracrine immune suppression in pancreatic cancer.
机构信息
Departments of Radiation Oncology and Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Cancer Cell. 2012 Jun 12;21(6):715-6. doi: 10.1016/j.ccr.2012.05.029.
PMID:22698396
Abstract
Pancreatic cancers are characterized by high levels of inflammatory cells and profound immune suppression. In this issue of Cancer Cell, Bayne et al. and Pylayeva-Gupta et al. show that KRAS-driven, tumor cell-secreted GM-CSF recruits myeloid-derived suppressor cells to the stroma to abrogate tumor cell immune clearance by killer T lymphocytes.
摘要
胰腺癌的特征是高水平的炎症细胞和深刻的免疫抑制。在本期《癌细胞》杂志上，Bayne 等人和 Pylayeva-Gupta 等人表明，KRAS 驱动的肿瘤细胞分泌的 GM-CSF 将髓源性抑制细胞募集到基质中，从而阻止杀伤性 T 淋巴细胞清除肿瘤细胞。
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