Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrberger Straße, Building 37, D-66421 Homburg/Saar, Germany.
Osteoarthritis Cartilage. 2012 Sep;20(9):1046-55. doi: 10.1016/j.joca.2012.05.010. Epub 2012 Jun 12.
To develop a new macroscopic scoring system which allows for an overall judgment of experimental articular cartilage repair and compare it with four existing scoring systems and high-field magnetic resonance imaging (MRI).
A new macroscopic scoring system was developed to assess the repair of cartilage defects. Cartilage repair was graded by three observers with different experience in cartilage research at 2-3 time points and compared with the protocol A of the international cartilage repair society (ICRS) cartilage repair assessment score, the Oswestry arthroscopy score, and macroscopic grading systems designed by Jung and O'Driscoll. Parameters were correlated with the two-dimensional (2D) magnetic resonance observation of cartilage repair tissue (MOCART) score based on a 9.4 T MRI as an external reference standard.
All macroscopic scores exhibited high intra- and interobserver reliability and high internal correlation. The newly developed macroscopic scoring system had the highest intraobserver [0.866 ≤ intraclass correlation (ICC) ≤ 0.895] and the highest interobserver reliability (ICC = 0.905) for "total points". Here, Cronbach's alpha indicated good homogeneity and functioning of the items (mean = 0.782). "Total points" of the 2D MOCART score correlated with all macroscopic scores (all P < 0.0001). The newly developed macroscopic scoring system yielded the highest correlation for the MRI parameter "defect fill" (rho = 0.765; all P < 0.0001).
"Total points" and "defect fill", two clinically relevant indicators of cartilage repair, can be reliably and directly assessed by macroscopic evaluation, using either system. These data support the use of macroscopic assessment to precisely judge cartilage repair in preclinical large animal models.
开发一种新的宏观评分系统，以对实验性关节软骨修复进行整体评估，并将其与四种现有的评分系统和高磁场磁共振成像（MRI）进行比较。
开发了一种新的宏观评分系统来评估软骨缺损的修复。由三名具有不同软骨研究经验的观察者在 2-3 个时间点对软骨修复进行分级，并与国际软骨修复学会（ICRS）的软骨修复评估评分协议 A、Oswestry 关节镜评分以及 Jung 和 O'Driscoll 设计的宏观分级系统进行比较。参数与基于 9.4 T MRI 的二维（2D）磁共振软骨修复组织观察（MOCART）评分相关，作为外部参考标准。
所有宏观评分均表现出高内和观察者间可靠性以及高内部相关性。新开发的宏观评分系统在“总分”方面具有最高的观察者内[0.866≤组内相关系数（ICC）≤0.895]和观察者间可靠性（ICC=0.905）。此处，Cronbach's alpha 表示项目具有良好的同质性和功能（平均值=0.782）。2D MOCART 评分的“总分”与所有宏观评分均相关（均 P<0.0001）。新开发的宏观评分系统与 MRI 参数“缺损填充”相关性最高（rho=0.765；均 P<0.0001）。
“总分”和“缺损填充”是软骨修复的两个具有临床意义的指标，可以通过宏观评估可靠且直接地进行评估，两种评分系统均适用。这些数据支持使用宏观评估来精确判断临床前大动物模型中的软骨修复情况。
