Wick Jeannette Y
University of Connecticut School of Pharmacy, Storrs, Connecticut, USA.
Consult Pharm. 2012 Jun;27(6):392-9. doi: 10.4140/TCP.n.2012.392.
External physical insult, an accidental blow, acceleration followed by rapid deceleration, or explosive blasts can cause traumatic brain injury (TBI). During the last few years, experts have realized that even mild blows to the head can cause lasting damage. Better understanding of how TBI occurs has improved the probability of survival for those with the most serious injuries. Graded using the Glasgow Coma Scale, TBI may leave its sufferers awake, in periods of alertness interspersed with cognitive confusion, or deep in coma. Falls recently displaced motor vehicle accidents as the leading cause of TBI. Elders are at high risk for falls and TBI, and they may be unaware of possible lasting complications. Pharmacologic therapies for patients who have suffered TBI are, by necessity, individualized.
外部身体损伤、意外撞击、加速后迅速减速或爆炸冲击都可能导致创伤性脑损伤(TBI)。在过去几年里,专家们已经认识到,即使是头部受到轻微撞击也可能造成永久性损伤。对TBI发生机制的深入了解提高了重伤患者的存活几率。根据格拉斯哥昏迷量表进行分级,TBI患者可能保持清醒,处于警觉期并伴有认知混乱,或者陷入深度昏迷。最近,跌倒取代机动车事故成为TBI的主要原因。老年人跌倒和发生TBI的风险很高,而且他们可能并未意识到可能出现的长期并发症。对于TBI患者的药物治疗必然是个体化的。