Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Chemotherapy. 2012;58(3):175-84. doi: 10.1159/000337084. Epub 2012 Jun 14.
Chinfloxacin is a novel synthetic fluoroquinolone with a structure similar to moxifloxacin. The in vitro activity of chinfloxacin was evaluated in the current study.
Chinfloxacin was tested against a total of 1,739 clinical isolates representing 23 species using the agar dilution method. Studies of bactericidal activity, including minimum bactericidal concentrations (MBC) and time-kill curve determinations, were conducted according to the recommendations of the Clinical and Laboratory Standards Institute.
Minimum inhibitory concentrations (MIC)(50)s and MIC(90)s of chinfloxacin were found to be the same or 2-fold lower than those of moxifloxacin against gram-positive isolates except for Streptococcus pyogenes (against which chinfloxacin showed similar MIC(50) as moxifloxacin but 2-fold higher MIC(90)), and the same as or 2-fold higher than those of moxifloxacin against gram-negative isolates. Chinfloxacin showed potent bactericidal activity with MBC/MIC ratios in the range of 1-2 for almost all the isolates tested. Time-kill curves further demonstrated chinfloxacin as a concentration-dependent bactericidal agent usually effective at concentrations of 2 MIC or higher.
Chinfloxacin showed similar in vitro activity as moxifloxacin.
盐酸克林沙星是一种新型合成氟喹诺酮类药物，其结构与莫西沙星相似。本研究评估了盐酸克林沙星的体外活性。
采用琼脂稀释法对代表 23 种细菌的 1739 株临床分离株进行了盐酸克林沙星的检测。根据临床和实验室标准协会的建议，进行了杀菌活性研究，包括最小杀菌浓度（MBC）和时间杀伤曲线测定。
盐酸克林沙星对革兰阳性菌的 MIC（50）和 MIC（90）与莫西沙星相同或低 2 倍，除了对化脓性链球菌（盐酸克林沙星对其的 MIC（50）与莫西沙星相同，但 MIC（90）高 2 倍），与莫西沙星对革兰阴性菌的 MIC（50）和 MIC（90）相同或低 2 倍。盐酸克林沙星对几乎所有受试分离株均具有较强的杀菌活性，MBC/MIC 比值在 1-2 之间。时间杀伤曲线进一步表明，盐酸克林沙星是一种浓度依赖性杀菌剂，在 2 倍 MIC 或更高浓度时通常有效。
盐酸克林沙星的体外活性与莫西沙星相似。
