Collège de France and Institut Pasteur, Paris, France.
Curr Opin Anaesthesiol. 2012 Aug;25(4):397-404. doi: 10.1097/ACO.0b013e32835561de.
Can a general anesthetic binding to its membrane receptors alter global brain activity to cause loss of consciousness?
The identification of the neurobiological mechanisms of conscious processing in awake patients that are altered by general anesthetics and the atomic structure of the general anesthetic's binding site.
An important feature of general anesthesia is a preferential inhibition of global feedback connectivity when general anesthetics bind to allosteric sites of gamma-aminobutyric acid receptors present in the cerebral cortex.
一种全身麻醉剂与它的膜受体结合是否能改变大脑的整体活动从而导致意识丧失？
在清醒的患者中，意识处理的神经生物学机制被全身麻醉剂改变，以及全身麻醉剂结合部位的原子结构已被确定。
全身麻醉的一个重要特征是当全身麻醉剂与大脑皮层中存在的γ-氨基丁酸受体的变构位点结合时，优先抑制全局反馈连通性。
