Yamate J, Tajima M, Kudow S, Sannai S
Nippon Institute for Biological Science, Tokyo, Japan.
Lab Anim. 1990 Oct;24(4):332-40. doi: 10.1258/002367790780865976.
Fifty male and 50 female BDF1 mice were observed allowing them to live out their life-span. Mortality up to 104 weeks of age was higher in males (42%) than in females (34%), and the 50% survival age was 112 weeks for males and 118 weeks for females. Body weight reached the peak at 82 weeks of age in males and 92 weeks of age in females, showing the mean body weight of 54.3 g for males and 48.0 g for females. The incidence of calculi and proteinaceous casts in the kidneys, that were not associated with exposure to chloroform, cell-alteration in the adrenal cortex, and islet cell hyperplasia in the pancreas was significantly higher in males than in females. On the other hand, hyaline droplet degeneration of the renal tubular epithelium, spindle cell proliferation in the adrenal cortex and milk-retention in the mammary glands occurred at a significantly higher incidence in females than in males. Cerebral mineralization in both sexes, atrophy and calcification of the testes and enlargement of the seminal vesicles of males, as well as cyst-formations in the ovary and endometrium of females developed at a very high incidence. Frequent neoplasms in males were hepatocellular adenomas and carcinomas, blood vessel tumours, pulmonary adenomas and carcinomas, and malignant lymphomas. In females, malignant lymphomas were the most common neoplasm, followed by blood vessel tumours, chromophobe pituitary adenomas and hepatocellular adenomas. Hepatocellular carcinomas developed only in males, whereas the histiocytic and lymphocytic types of malignant lymphomas and chromophobe cell adenomas arose solely or at a significantly higher incidence in females than in males.
观察了50只雄性和50只雌性BDF1小鼠直至其自然寿命结束。104周龄前的死亡率雄性（42%）高于雌性（34%），雄性的50%存活年龄为112周，雌性为118周。雄性体重在82周龄时达到峰值，雌性在92周龄时达到峰值，雄性平均体重为54.3克，雌性为48.0克。未接触氯仿的情况下，雄性肾脏中结石和蛋白管型的发生率、肾上腺皮质细胞改变以及胰腺胰岛细胞增生显著高于雌性。另一方面，肾小管上皮细胞的透明滴状变性、肾上腺皮质的梭形细胞增殖以及雌性乳腺中的乳汁潴留发生率显著高于雄性。两性均有脑矿化，雄性睾丸萎缩和钙化以及精囊增大，雌性卵巢和子宫内膜形成囊肿的发生率很高。雄性常见的肿瘤有肝细胞腺瘤和癌、血管肿瘤、肺腺瘤和癌以及恶性淋巴瘤。在雌性中，恶性淋巴瘤是最常见的肿瘤，其次是血管肿瘤、嫌色性垂体腺瘤和肝细胞腺瘤。肝细胞癌仅发生在雄性中，而组织细胞性和淋巴细胞性恶性淋巴瘤以及嫌色细胞腺瘤仅在雌性中出现或在雌性中的发生率显著高于雄性。
