Department of Neurology, Charité University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, Germany.
Mov Disord. 2012 Jul;27(8):1063-6. doi: 10.1002/mds.25078. Epub 2012 Jun 14.
Local field potentials were recorded from the subthalamic nucleus (STN) in a patient with dystonia to further elucidate disease-specific aspects of basal ganglia oscillatory activity.
STN local field potentials and electromyograms (EMGs) from dystonic muscles were recorded to provide an estimate of the power spectra and coherence between the STN activity and EMG.
STN power spectra revealed a distinct peak at approximately 7 Hz in our patient. This finding is similar to the pallidal activity seen in dystonic patients but clearly different from the subthalamic beta activity of patients with Parkinson's disease. Significant coherence between STN activity and EMG was present in the 4- to 12-Hz band in this patient.
Dystonia is associated with pathological activity in the theta range present throughout the cortical-basal ganglia network. This activity differs from that in Parkinson's disease, suggesting that different movement disorders may involve distinct oscillatory circuit disturbances. © 2012 Movement Disorder Society.
对一名伴有肌张力障碍的患者的丘脑底核（STN）进行局部场电位记录，以进一步阐明基底神经节振荡活动的特定疾病方面。
记录来自痉挛肌的 STN 局部场电位和肌电图（EMG），以提供 STN 活动与 EMG 之间的功率谱和相干性的估计。
在我们的患者中，STN 功率谱在大约 7 Hz 处显示出一个明显的峰。这一发现与肌张力障碍患者的苍白球活动相似，但与帕金森病患者的 STN β活动明显不同。在这名患者中，STN 活动与 EMG 之间存在显著的相干性，存在于 4-12 Hz 频段。
肌张力障碍与整个皮质-基底神经节网络中存在的病理性θ范围活动有关。这种活动与帕金森病不同，提示不同的运动障碍可能涉及不同的振荡电路紊乱。© 2012 运动障碍学会。
