Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, Korea.
Invest Ophthalmol Vis Sci. 2012 Jul 31;53(8):5044-51. doi: 10.1167/iovs.11-9401.
We attempted to understand better the relationship between the macular visual field (VF) mean sensitivity (MS) assessed by standard automated perimetry (SAP) and the ganglion cell complex thickness (GCCT), and macular peripapillary retinal nerve fiber layer thickness (mpRNFLT) assessed by spectral domain optical coherence tomography (SD-OCT, RTVue-100) in open-angle glaucoma (OAG) patients.
We enrolled in the study 217 OAG patients with baseline intraocular pressure (IOP) in the statistically normal range. GCCT and mpRNFLT measurements, using the ganglion cell complex (GCC) and the optic nerve head (ONH) modes of RTVue-100 OCT, were obtained for analysis. Macular VF sensitivity was recorded in the dB and 1/L scales. The relationship of the function (MS) and structure (GCCT, mpRNFLT) was sought globally and in two VF sectors (superior and inferior).
The relationship of the macular VF sensitivity (dB) to the GCC, and mpRNFL global (R(2) = 0.111, 0.127) and sectoral (superior R(2) = 0.358, 0.171; inferior R(2) = 0.227, 0.263) thicknesses were statistically significant (all P < 0.05). The relationship of the macular VF sensitivity to the GCCT differed significantly from that of the macular VF sensitivity to the mpRNFL in the superior VF sector (R(2) = 0.358 vs. 0.171, P < 0.05).
GCCT determined by SD-OCT (RTVue-100) showed a statistically significant structure-function association with macular VF, and the strength of the association was greater than that of the mpRNFL with macular VF in the superior central VF area.
我们试图更好地理解在开角型青光眼（OAG）患者中，通过标准自动视野计（SAP）评估的黄斑视野（VF）平均敏感度（MS）与通过光谱域光学相干断层扫描（SD-OCT，RTVue-100）评估的神经节细胞复合体厚度（GCCT）和黄斑区神经纤维层厚度（mpRNFLT）之间的关系。
我们招募了 217 名基线眼压（IOP）处于统计学正常范围内的 OAG 患者参与研究。使用 RTVue-100 OCT 的神经节细胞复合体（GCC）和视神经头（ONH）模式获得 GCCT 和 mpRNFLT 测量值进行分析。在 dB 和 1/L 标度上记录黄斑 VF 敏感度。在全局和两个 VF 区域（上方和下方）中寻找功能（MS）和结构（GCCT、mpRNFLT）之间的关系。
黄斑 VF 敏感度（dB）与 GCC 和 mpRNFL 全局（R²=0.111，0.127）和扇形（上方 R²=0.358，0.171；下方 R²=0.227，0.263）厚度之间存在统计学显著关系（均 P<0.05）。黄斑 VF 敏感度与 GCCT 的关系与黄斑 VF 敏感度与 mpRNFL 的关系在上方 VF 区域有显著差异（R²=0.358 与 0.171，P<0.05）。
由 SD-OCT（RTVue-100）确定的 GCCT 与黄斑 VF 具有统计学显著的结构-功能相关性，且在上方中央 VF 区域，与黄斑 VF 的相关性强于与 mpRNFL 的相关性。
