频域光相干断层扫描测量视野敏感性与黄斑神经节细胞复合体厚度的关系。

Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography.

机构信息

Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

出版信息

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6401-7. doi: 10.1167/iovs.09-5035. Epub 2010 Jul 14.

DOI:10.1167/iovs.09-5035

PMID:20631238

Abstract

PURPOSE

To evaluate the strength and pattern of the relationship between visual field (VF) mean sensitivity (MS), assessed by standard automated perimetry (SAP), and macular ganglion cell complex thickness (GCCT), measured with spectral-domain optical coherence tomography (SD-OCT).

METHODS

Ninety-seven glaucoma patients were enrolled. GCCT, determined by ganglion cell complex (GCC) scanning, and two peripapillary retinal nerve fiber layer thickness (pRNFLT) measurements, using the NHM4 (RNFL1) and RNFL 3.45 (RNFL2) modes, were recorded. MS was recorded on the decibel (dB) and 1/L scales. The relationship between function (MS) and structure (GCC, pRNFLT) was sought.

RESULTS

The association of MS (in decibels) with GCC global (r = 0.445) and sectoral (superior, r = 0.528; inferior, r = 0.370) thicknesses was not significantly different from that of MS to global (RNFL1, r = 0.505; RNFL2, r = 0.498) and sectoral (RNFL 1 superior, r = 0.559; inferior, r = 0.440; RNFL 2 superior, r = 0.535; inferior, r = 0.443) pRNFLT, on linear regression analysis. The relationship pattern was curvilinear on the dB scale against GCCT and RNFLT. Logarithmic regression of MS (using both the dB and 1/L scales) against GCCT and RNFLT was better than linear regression in describing the pattern of association.

CONCLUSIONS

GCCT, determined by SD-OCT, showed correlation to MS of a strength similar to that demonstrated between MS and pRNFLT.

摘要

目的

评估通过标准自动视野计（SAP）评估的视野（VF）平均敏感度（MS）与通过光谱域光相干断层扫描（SD-OCT）测量的黄斑神经节细胞复合体厚度（GCCT）之间的关系的强度和模式。

方法

纳入 97 例青光眼患者。记录使用 NHM4（RNFL1）和 RNFL 3.45（RNFL2）模式的节细胞复合体（GCC）扫描确定的 GCCT 和两个视盘周围视网膜神经纤维层厚度（pRNFLT）测量值。MS 以分贝（dB）和 1/L 标度记录。寻找功能（MS）与结构（GCC、pRNFLT）之间的关系。

结果

MS（dB）与 GCC 全局（r = 0.445）和扇区（上侧，r = 0.528；下侧，r = 0.370）厚度的关联与 MS 与全局（RNFL1，r = 0.505；RNFL2，r = 0.498）和扇区（RNFL 1 上侧，r = 0.559；下侧，r = 0.440；RNFL 2 上侧，r = 0.535；下侧，r = 0.443）pRNFLT 的关联无显著差异线性回归分析。在 dB 标度上，MS 与 GCCT 和 RNFLT 的关系模式呈曲线关系。MS（使用 dB 和 1/L 标度）对数回归对 GCCT 和 RNFLT 的描述模式优于线性回归。