INRA, UMR866 Dynamique Musculaire Et Métabolisme, 2 Place Viala, 34060 Montpellier, France.
Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C475-85. doi: 10.1152/ajpcell.00125.2012. Epub 2012 Jun 13.
The AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status switch regulating several systems including glucose and lipid metabolism. Recently, AMPK has been implicated in the control of skeletal muscle mass by decreasing mTORC1 activity and increasing protein degradation through regulation of ubiquitin-proteasome and autophagy pathways. In this review, we give an overview of the central role of AMPK in the control of skeletal muscle plasticity. We detail particularly its implication in the control of the hypertrophic and atrophic signaling pathways. In the light of these cumulative and attractive results, AMPK appears as a key player in regulating muscle homeostasis and the modulation of its activity may constitute a therapeutic potential in treating muscle wasting syndromes in humans.
腺苷酸活化蛋白激酶（AMPK）是一种丝氨酸/苏氨酸蛋白激酶，作为细胞能量状态的传感器，调节包括葡萄糖和脂质代谢在内的多个系统。最近，AMPK 通过调节泛素-蛋白酶体和自噬途径来降低 mTORC1 活性和增加蛋白质降解，从而参与控制骨骼肌质量。在这篇综述中，我们概述了 AMPK 在控制骨骼肌可塑性中的核心作用。我们特别详细介绍了其在控制肥大和萎缩信号通路中的作用。鉴于这些累积的有吸引力的结果，AMPK 似乎是调节肌肉内稳态的关键因素，其活性的调节可能在治疗人类肌肉消耗综合征方面具有治疗潜力。
