Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Front Integr Neurosci. 2012 Jun 12;6:30. doi: 10.3389/fnint.2012.00030. eCollection 2012.
Even in absence of sensory stimuli cortical networks exhibit complex, self-organized activity patterns. While the function of those spontaneous patterns of activation remains poorly understood, recent studies both in vivo and in vitro have demonstrated that neocortical neurons activate in a surprisingly similar sequential order both spontaneously and following input into cortex. For example, neurons that tend to fire earlier within spontaneous bursts of activity also fire earlier than other neurons in response to sensory stimuli. These "default patterns" can last hundreds of milliseconds and are strongly conserved under a variety of conditions. In this paper, we will review recent evidence for these default patterns at the local cortical level. We speculate that cortical architecture imposes common constraints on spontaneous and evoked activity flow, which result in the similarity of the patterns.
即使在没有感觉刺激的情况下，皮质网络也会表现出复杂的、自我组织的活动模式。虽然这些自发激活模式的功能还不太清楚，但最近的体内和体外研究都表明，新皮层神经元在自发活动和皮层输入时以惊人相似的顺序激活。例如，在自发活动爆发中倾向于较早发射的神经元，在对感觉刺激的反应中也比其他神经元更早发射。这些“默认模式”可以持续数百毫秒，并且在各种条件下都得到了强烈的保持。在本文中，我们将回顾最近在局部皮质水平上对这些默认模式的证据。我们推测，皮质结构对自发和诱发活动流施加了共同的约束，这导致了模式的相似性。
